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[会议论文] 作者:Yike Cai,Chenshu Xu,Peiyi Chen,Junqing Hu,Rong Hu,Min Huang,Huichang Bi, 来源:2015广东省药师周大会 年份:2014
Introduction: Monolayers of Caco-2 cells have been widely accepted as one of the well-established in vitro models to predict intestinal drug permeability and absorption in humans.However,the procedure...
[期刊论文] 作者:Huizhen Zhang,Yongtao Wang,Lihuan Guan,Yixin Chen,Panpan Chen,Jiahong Sun,Frank J.Gonzalez,Min Huang,Huichang Bi, 来源:药物分析学报:英文版 年份:2021
Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitocho......
[期刊论文] 作者:Huizhen Zhang,Yongtao Wang,Lihuan Guan,Yixin Chen,Panpan Chen,Jiahong Sun,Frank J.Gonzalez,Min Huang,Huichang Bi, 来源:药物分析学报(英文版) 年份:2021
Lipotoxicity,caused by intracellular lipid accumulation,accelerates the degenerative process of cellular senescence,which has implications in cancer development...
[会议论文] 作者:Pan Chen,Hang Zeng,Yongtao Wang,Xiaomei Fan,Chenshu Xu,Rongrong Deng,Xunian Zhou,Huichang Bi,Min Huang, 来源:2015广东省药师周大会 年份:2014
Oleanolic acid (OA) is a natural triterpenoid and has been demonstrated to protect against varieties of hepatotoxicants.However recently,OA at high doses was reported to produce apparent cholestasis i...
[期刊论文] 作者:Xi Li,Chenshu Xu,Fulin Jiang,Yufei Mo,Xiaomei Fan,Yaoting Li,Yiming Jiang,Dongshun Li,Min Huang,Huichang Bi, 来源:药学学报(英文版) 年份:2017
Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet (WZ),a preparation of extract from Schisandra sphena...
[会议论文] 作者:Deng,Chenshu Xu,Xiao Chen,Pan Chen,Yongtao Wang,Xunian Zhou,Jing Jin,Lu Niu,Mengjia Ying,Min Huang,Huichang Bi, 来源:2015广东省药师周大会 年份:2014
The pregnane X receptor (PXR,NR1I2),a member of the nuclear receptor (NR) superfamily,is activated by a number of clinically prescribed drugs and herbal extracts.The inducible expression of several im...
[期刊论文] 作者:Yiming Jiang,Xinpeng Yao,Shuguang Zhu,Xiao Yang,Ruimin Wang,Jianing Tian,Frank J.Gonzalez,Min Huang,Huichang Bi, 来源:药学学报(英文版) 年份:2021
The constitutive androstane receptor(CAR,NR3I1)belongs to nuclear receptor superfamily.It was reported that CAR agonist TCPOBOP induces hepatomegaly but the und...
[期刊论文] 作者:Dongyang Liu,Xiangyu Hou,Lan Tang,Xin Wang,Yuanfeng Lyu,Xiaoyan Chen,Kexin Liu,Ai-Ming Yu,Zhong Zuo,Huichang Bi, 来源:药学学报(英文版) 年份:2019
Pharmacokinetics (PK) is the study of the absorption,distribution,metabolism,and excretion (ADME) processes of a drug.Understanding PK properties is essential f...
[期刊论文] 作者:Wenzhou Li,Panpan Chen,Yiming Jiang,Jiahong Sun,Yixin Chen,Pan Chen,Lihuan Guan,Yajie Wen,Min Huang,Huichang Bi, 来源:药学学报(英文版) 年份:2021
Acetaminophen(APAP)overdose is the leading cause of drug-induced liver injury,and its prognosis depends on the balance between hepatocyte death and regeneration...
[会议论文] 作者:Jiahong Sun,Kaili Fu,Lihuan Guan,Huizhen Zhang,Yiming Jiang,Xi Li,Xuezhen Zeng,Xiao Chen,Min Huang,Huichang Bi, 来源:2018第23届广东省药师周大会 年份:2017
BACKGROUND AND PURPOSE: Tumor suppressor p53 is traditionally recognized as a surveillance molecule to preserve genome integrity.Recent studies have emerged on discovering its functions in metabolic d...
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