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[会议论文] 作者：Yongli Du,Hao Ling,Jingkang Shen,Qunyi Li,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Fragment-docking-oriented de novel design for the A,D and C site of protein tyrosine phosphatase 1B(PTP1B)and optimization led to the discovery of novel scaffold and chemical easy N-(2,5-diethoxy-phen...
[会议论文] 作者：Mengzhu Xue,Bing Xiong,Xin Xie,Hualiang Jiang,Jingkang Shen,
来源：2009长三角药物化学研讨会 年份：2009
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[期刊论文] 作者：Bibo YAN,Mengzhu XUE,Bing XIONG,Ke LIU,Dingyu HU,Jingkang SHEN,
来源：中国药理学报(英文版) 年份：2009
Aim:The search for molecules whose bioactivities are similar to those of given compounds or to optimize the initial lead compounds from high throughput screenin...
Identification and Optimization of 2-thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromod
[会议论文] 作者：Lele Zhao,Danyan Cao,Jianhua He,Bing Xiong,Zehong Miao,Jingkang Shen,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
Epigenetic pathways can modulate gene expression by controlling and interpreting chromatin modifications....
[会议论文] 作者：Jing Ren,Jian Li,Tong Chen,Yechun Xu,Bing Xiong,Jianhua He,Jingkang Shen,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
HSP90(heat shock protein 90) is a molecular chaperone to assist other proteins folding properly in response to cell stress,and is one of the most abundant proteins expressed in cells.Recent studies we...
[会议论文] 作者：Bing Xiong,Feng Shi,Jing Ren,Danqi Chen,Yechun Xu,Naixia Zhang,Jianhua He,Jingkang Shen,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
HSP90(heat shock protein 90)is a molecular chaperone to assist other proteins folding properly in response to cell stress,and is one of the most abundant pr...
Design, Synthesis and Biological Evaluation of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-4-Substituted-1H
[会议论文] 作者：Zhen Zhang,Dongmei Zhao,Yang Dai,Maosheng Cheng,Meiyu Geng,Yuchi Ma,Jing Ai,Bing Xiong,Jingkang Shen,
来源：2016年长三角药物化学研讨会 年份：2016
Tyrosine kinase fibroblast growth factor receptor (FGFR),which is aberrant in various cancer types,is a promising target for cancer therapy[1-4].Thus,discovery of potent and selective FGFR inhibitors...
P-MMAE,a novel antibody-drug conjugate,is highly effective against primary HER2 overexpressing gastr
[会议论文] 作者：Tao Meng,Lanping Ma,Xin Wang,Hongli Peng,Ting Yu,Yongliang Zhang,Lin Chen,Yiyi Chen,Jingkang Shen,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Gastric cancer is one of the most frequent human malignancies and the second leading cause of cancer-related death in the world.Human epidermal growth factor receptor 2(HER2)is overexpressed in~20%of...
,Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing h
[期刊论文] 作者：Yiping ZHU,Kun XIAO,Haiping YU,Lanping MA,Bing XIONG,Haiyan ZHANG,Xin WANG,Jingya LI,Jia LI,Jingkang SHEN,
来源：中国药理学报(英文版) 年份：2009
Aim:The aim of this study was to design and synthesize a series of high activity compounds against aspartyl protease β-secretase (BACE-1) bearing hydroxyethyle...
[期刊论文] 作者：Aijun Shen,Guanghua Fang,Hongchun Liu,Minmin Zhang,Shuai Tang,Bing Xiong,Lanping Ma,Meiyu Geng,Jingkang Shen,
来源：Acta Pharmaceutica Sinica B 年份：2016
Histone acetylation is a critical process in the regulation of chromatin structure and gene expression.Histone deacetylases(HDACs)remove the acetyl group,leadin...
[会议论文] 作者：Tongchao Liu,Jianpeng Liang,Qiang Yin,Bing Xiong,Dongmei Zhao,Qidong You,Guohua Chen,Yue-Lei Chen,Jingkang Shen,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Introducing new methods for mild and stereoselective glycosylation(Scheme 1): For O-glycosides,1)Using beta-pinene as acid scavenger,direct glycosylation of taxanes was rendered possible for the first...
[会议论文] 作者：Huayong Zhou,Jingkang Shen,Yi Wang,Lanping Ma,Xin Wang,Lin Chen,Yi Chen,Jian Ding,Tao Meng,Linhua Meng,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Phosphoinositide-3-kinase(PI3K) has attracted vast attention as a promising target for cancer therapeutics because the deregulation of the PI3K/Akt/mTOR signaling pathway is frequently observed in a w...
[会议论文] 作者：Qiancheng Shen,Mingyue Zheng,Xiaomin Luo,Cheng Luo,Xian Liu,Yun Du,Jing Li,Weiliang Zhu,Jingkang Shen,
来源：第十一届全国计算(机)化学学术会议 年份：2011
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[会议论文] 作者：Qiancheng Shen,Jingkang Shen,Hualiang Jiang,Bing Xiong,Mingyue Zheng,Xiaomin Luo,Cheng Luo,Xian Liu,Yun,
来源：第十一届全国计算(机)化学学术会议 年份：2011
...
Stereoselective and Regioselective Preparations of C-Pentopyranosides and Formal Synthesis of Omarig
[会议论文] 作者：,Jian Hou,You Li,Jianpeng Liang,Bing Xiong,Chungang Li,Guohua Chen,Maosheng Cheng,Dongmei Zhao,Jingkang Shen,
来源：2016年长三角药物化学研讨会 年份：2016
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[期刊论文] 作者：,Ruifeng Wang,Yinglei Gao,Lanlan Li,Yuchi Ma,Zhiwei Qian,Yuelei Chen,Maosheng Cheng,Meiyu Geng,Jingkang Shen,
来源：药学学报（英文版） 年份：2019
Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors (FGFRs).Although there is no selective FGFR inhibitors in...
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