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On the Evolution of Function in Two Manganese-Dependent Enzymes of Oxalate CatabolismA Single Residu
[会议论文] 作者：Nigel G.J.Richards,
来源：2007 Enzyme Engineering Conference(国际酶工程学术会议) 年份：2007
The molecular mechanisms that mediate evolution and creation of enzyme catalysts are constrained by both protein structure/dynamics and the chemical imperat...
[会议论文] 作者：Nigel G.J.RICHARDS,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Oxalate is a highly toxic molecule that contains an unreactive C-C bond and has a half-life of approximately 10,000 years [1].Biology has evolved three solutions to the problem of catalyzing the break...
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