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,Intratumor heterogeneity, variability and plasticity: questioning the current concepts in classific
[期刊论文] 作者：Ralf Weiskirchen,
来源：肝胆外科与营养 年份：2016
In the classical view, the formation of a primary tumor is the consequence of a mutational event that first affects a single cell that subsequently passes throu...
[期刊论文] 作者：Frank Tacke,Ralf Weiskirchen,
来源：肝胆外科与营养 年份：2014
The liver not only fulfills manifold functions in metabolism, but is also a central organ for immunology. Due to its anatomical location, the liver is exposed t...
[期刊论文] 作者：Hans-Theo Schon,Ralf Weiskirchen,
来源：肝胆外科与营养 年份：2014
Members of the transforming growth factor-β (TGF-β) family are potent regulatory cytokines that affect multiple cell types of the immune system mediating pro-...
,Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immu
[期刊论文] 作者：Ralf Weiskirchen,Frank Tacke,
来源：肝胆外科与营养 年份：2014
The liver is a central immunological organ. Liver resident macrophages, Kupffer cells (KC), but also sinusoidal endothelial cells, dendritic cells (DC) and othe...
,Immune surveillance of liver cancer in non-alcoholic fatty liver disease: excess lipids cause CD4 T
[期刊论文] 作者：Ralf Weiskirchen,Frank Tacke,
来源：肝胆外科与营养 年份：2016
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries with an increasing prevalence worldwide (1). Large-scale...
[期刊论文] 作者：Dileep G NAIR,Ralf WEISKIRCHEN,Salma K Al-MUSHARAFI,
来源：中国药理学报（英文版） 年份：2015
...
[期刊论文] 作者：高春芳,孔宪涛,A.M.Gressner,Ralf Weiskirchen,
来源：中华微生物学和免疫学杂志 年份：2001
β型转化生长因子 (ＴＧＦ β)有 5种不同的异构体 ,其中ＴＧＦ β1研究最为深入 ,由于ＴＧＦ β1对多种脏器纤维化及肿瘤的发生、发展有关而倍受关注。哺乳动物细胞合成的ＴＧＦ β1前体含 390个氨基......
[期刊论文] 作者：Steffen K Meurer,Muhammad Alsamman,David Scholten,Ralf Weiskirchen,,
来源：World Journal of Biological Chemistry 年份：2014
Endoglin, also known as cluster of differentiation CD105, was originally identified 25 years ago as a novel marker of endothelial cells. Later it was shown that...
[期刊论文] 作者：高春芳,孔宪涛,A.M.Gressner,RALF WEISKIRCHEN,
来源：中华微生物学和免疫学杂志 年份：2001
...
Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis i
[期刊论文] 作者：Senait Mengsteab,Carmen G.Tag,Claus Hellerbrand,Frank Lammert,Axel M.Gressner,Ralf Weiskirchen,,
来源：World Journal of Gastroenterology 年份：2005
AIM: Considerable attention is focused on polymorphisms in the gene encoding transforming growth factor-pi (TGF-β1), a multifunctional cytokine that is in turn...
[期刊论文] 作者：Axel M Gressner,Birgit Lahme,Steffen K Meurer,Olav Gressner,Ralf Weiskirchen,
来源：世界胃肠病学杂志（英文版） 年份：2006
AIM: To study the expression of cystatin C (CysC), its regulation by transforming growth factor-β1 (TGF-β1)and platelet-derived growth factor (PDGF) and the p...
W5-06 Transforming Growth Factor β1 Gene Variants Increase Transcription and are Associated with Liv
[会议论文] 作者：Chunfang Gao,Hao Wang,Qiang Ji,Ralf Weiskirchen,Yunpeng Zhao,Zaixing Yang,A.M Gressner,
来源：第一届世界华人免疫学大会(International Conference on Immunology 2007) 年份：2007
...
[期刊论文] 作者：Elke Kaemmerer,Anne Peuscher,Andrea Reinartz,Christian Liedtke,Ralf Weiskirchen,Jürgen Kopitz,Nikolaus,
来源：World Journal of Gastroenterology 年份：2011
AIM:To investigate whether human acyl-CoA synthetase 5(ACSL5) is sensitive to the ACSL inhibitor triacsin C.METHODS:The ACSL isoforms ACSL1 and ACSL5 from rat a...
Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis i
[期刊论文] 作者：Gressner,Ralf Weiskirchen,
来源：世界胃肠病学杂志（英文版） 年份：2005
AIM: Considerable attention is focused on polymorphisms in the gene encoding transforming growth factor-β1 (TGF-β1),a multifunctional cytokine that is in t a...
[期刊论文] 作者：Andreas Geier,Carsten Gartung,Igor Theurl,Guenter Weiss,Frank Lammert,Christoph G.Dietrich,Ralf Weiskirchen,
来源：World Journal of Gastroenterology 年份：2005
AIM:To report a patient with C282Y homozygocity,depleted body iron and intestinal atrophy caused by celiac disease (CD) who experienced resolution of the entero...
[期刊论文] 作者：Elke Kaemmerer,Patrick Plum,Christina Klaus,Ralf Weiskirchen,Christian Liedtke,Maximilian Adolf,Angela,
来源：World Journal of Gastrointestinal Pathophysiology 年份：2010
Free fatty acids are essential dietary components and recognized as important molecules in the maintenance of cellular homeostasis.In the last decade,the molecu...
[期刊论文] 作者：王皓,杨再兴,高春芳,万漠彬,王晓今,Senait Mengsteab,Axel M.Gressner,Ralf Weiskirchen,
来源：第二军医大学学报 年份：2004
目的:探讨TGF-β1基因多态性与肝炎后肝纤维化的关系。方法:以实时荧光PCR结合熔点曲线分析,建立可高通量检测TGF-β1编码区3个单核苷酸多态性(SNPs)位点的LightCycler方法,...
[期刊论文] 作者：王皓,杨再兴,高春芳,徐玲玲,屠小卿,赵文静,孔宪涛,Axel M.Gressner,Ralf Weiskirchen,,
来源：中国免疫学杂志 年份：2006
目的:探讨转化生长因子-β1(TGF-β1)分子表达水平及其编码区基因多态性与多发性骨髓瘤(Mu ltip le myelo-m a,MM)的关系。方法:应用ELISA方法检测标本血浆TGF-β1的浓度,应...
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