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Inhibition of p70 S6 kinase(S6K1)activity induces autophagy through TAK1-mediated AMPK and JNK activ
[会议论文] 作者:Xiulong Xu,Jing Sun,Michelle E.Doscas,Ashley J.Williamson,Ruirong Song,Jingsong Zhou,Jun Sun,Xinan Jiao,
来源:江苏省畜牧兽医学会成立60周年庆典暨2015年学术年会 年份:2015
mTOR activation is known to suppress autophagy by phosphorylating ULK1 at S757 and deactivating its enzymatic activity.Here we report that feedback activation of the mTOR-PI3K pathway by two S6K1 inhi...
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