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[会议论文] 作者：Tian-Le Xu,
来源：第三届国际神经疾病大会暨2016脑网络与脑疾病高峰论坛 年份：2016
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[会议论文] 作者：Tian-Le XU,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
The acid-sensing ion channel (ASIC) has a prominent role in tissue pH-sensing and neuronal signalling.Subunits of ASICs are members of the degenerin/epithelial Na+ channel protein superfamily.To date,...
[会议论文] 作者：Tian-Le Xu,Yi-Zhi Wang,
来源：第十三次中国生物物理学术大会 年份：2013
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[会议论文] 作者：De-Guang WANG,Tian-Le XU,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Neural inhibition in the brain is mainly mediated by onotropic GABA type A receptors.Apart from the GABA type receptors,both K-C1 cotransporter isoform 2 and the GABA-synthesizing enzyme,glutamic acid...
[会议论文] 作者：Tian-Le Xu,Yi-Zhi Wang,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
Necrosis is an important form of cell demise during organ development and diseases.Traditionally, necrosis has been considered as an accidental, uncontrolled form of cell death.Increasing evidence now...
ASIC1a channels contribute to dendritic spine development of striatal medium spiny neurons (MSNs) an
[会议论文] 作者：Zhe Yu,Tian-Le Xu,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
Acid-sensing ion channel la (ASIC1a) is widely expressed in nervous systems, contributing to synaptic activity, learning and memory.Although previous research had reported that ASIC1a channels contrib...
Molecular Mechanism of Constitutive Endocytosis of Acid-Sensing Ion Channel 1a and Its Protective Fu
[会议论文] 作者：Wei-Zheng Zeng,Tian-Le Xu,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the peripheral and CNSs, which critically contribute to a variety of pathophysiological conditions that involve t...
Spatiotemporal specific regulation of synaptic morphology and function by GABA uptake underlies emer
[会议论文] 作者：Yan-Jiao Wu,Tian-Le Xu,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
GABA transporter 1 (GAT1) plays an important role in GABA reuptake from GABAergic synaptic cleft, which mainly distributes at GABAergic presynaptic terminals.When GAT1 is knocked out, the mice manifes...
[会议论文] 作者：Yi-Zhi Wang,Tian-Le Xu,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
Acid-sensing ion channel 1a (ASIC1a) is the key proton receptor in nervous systems, mediating acidosis-induced neuronal injury in many neurological disorders, such as ischemic stroke.Up to now, functi...
Ion channel subunit ASIC1a is localized in mitochondria and regulates mitochondrial permeability tra
[会议论文] 作者：Yi-Zhi Wang,Tian-Le Xu,
来源：The 3rd Ion Channel Conference: Ion channels-Structure, Func 年份：2011
Acid sensing ion channels (ASICs), which serve as the key receptors of extracellular protons, are known to be expressed in the surface of neuronal plasma membrane.In this study, we showed that ion cha...
ASIC1a regulates insular long-term depression and is required for extinction of conditioned taste av
[会议论文] 作者：Wei-Guang Li,Tian-Le Xu,
来源：2016年国际生理学学术大会 年份：2016
The synaptic function of acid-sensing ion channel 1a(ASIC1a)is emerging to be understood.Here,we identify a crucial role of ASIC1a in synaptic plasticity at mouse insular synapses.Whereas genetic abla...
[期刊论文] 作者：Wei-Zheng Zeng,Tian-Le Xu,
来源：神经科学通报（英文版） 年份：2012
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[期刊论文] 作者：Di-Shi Liu,Tian-Le Xu,
来源：神经科学通报（英文版） 年份：2019
The autonomic nervous system controls various internal organs and executes crucial functions through sophisticated neural connectivity and circuits.Its dysfunction causes an imbalance of homeostasis and numerous human disorders.In the past ......
[期刊论文] 作者：Shao-Ling Han,Tian-Le Xu,
来源：神经科学通报（英文版） 年份：2018
Memory is a crucial biological function conserved across almost all organisms.Once established and consolidated,a memory is considered stable and long-lasting unless it is disrupted or manipulated by behavioral,physical,or chemical interven......
[期刊论文] 作者：Wei-Guang Li,Tian-Le Xu,
来源：神经科学通报（英文版） 年份：2012
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[会议论文] 作者：Ye Yu,Rui Wang,Tian-Le Xu,
来源：The 3rd Ion Channel Conference: Ion channels-Structure, Func 年份：2011
Acid-sensing ion channel 3 (ASIC3) channels are extraeellular proton (H+)-aetivated trimeric sodium channels.Generally, proton-induced ASIC3 currents consis...
Inter-subunit interaction between Knuckle and Finger domains contributes to proton-induced gating of
[会议论文] 作者：Wei-Guang Li,Hualiang Jiang,Tian-Le Xu,
来源：2009 harbin conference on lon channels in technology and dru 年份：2009
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[会议论文] 作者：Di-Shi Liu,Xing-Lei Song,Tian-Le Xu,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
Acid-sensing ion channel (ASIC) is a family of cation channels that are activated by extracellular pH reduction.Subunit l a (ASIC1a) is wildly expressed throughout the neural system and has been repor...
2-guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid
[会议论文] 作者：Xian Xiao,Michael Zhu,Tian-Le Xu,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
The pentameric a type γ-aminobutyric acid receptors (GABAARs) are the major inhibitory neurotransmitter receptors in the nervous system and have long been considered as important pharmaceutical target...
Roles of acid-sensing ion channel 1a in synaptic plasticity in the hippocampus:Revisited by multi-el
[会议论文] 作者：Ming-Gang Liu,Hu-Song Li,Wei-Guang Li,Tian-Le Xu,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Acid-sensing ion channels(ASICs)are proton-gated cation channels involved in a variety of physiological and pathological functions in the central nervous system.However,the roles of ASICs in central s...
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