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Population pharmacokinetic and pharmacodynamic evaluation of Xuesaitong injection, a typical multipl
[期刊论文] 作者：LI Xiao-yu,WANG Guang-ji,XIONG,
来源：中国临床药理学与治疗学 年份：2007
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[期刊论文] 作者：HE Hui,陈西敬,WANG Guang-ji,
来源：中国药科大学学报 年份：2008
目的:通过体内和体外模型研究多药耐药相关蛋白(Mrp-2)外排底物溴磺肽钠对反式白藜芦醇(trarts-resveratrol,TR)肠道吸收的影响,并对转运体在TR肠道吸收中的作用进行研究.方...
Dynamic evolution of transposable elements,demographic history,and gene content of paleognathous bir
[期刊论文] 作者：Zong-Ji Wang,Guang-Ji Chen,Guo-Jie Zhang,Qi Zhou,
来源：动物学研究 年份：2021
Palaeognathae includes ratite and tinamou species that are important for understanding early avian evolution.Here,we analyzed the whole-genome sequences of 15 p...
NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small
[期刊论文] 作者：LIU Hui-Ying,LI Qing-Ran,CHENG Xue-Fang,WANG Guang-Ji,HAO Hai-Ping,,
来源：Chinese Journal of Natural Medicines 年份：2016
Nicotinamide phosphoribosyltransferase(NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD~+, essential for a number of enzymes and...
[期刊论文] 作者：WANG Jing,WANG Hong,PENG Ying,WANG Guang-Ji,HAO Hai-Ping,,
来源：Chinese Journal of Natural Medicines 年份：2016
Isochlorogenic acid A(ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant...
[期刊论文] 作者：孙杰,LIANG Yan,谢林,KANG An,谢媛,WANG Guang-ji,
来源：中国药科大学学报 年份：2008
目的:建立生物样本中长春瑞滨的LC-MS测定方法,研究长春瑞滨大鼠体内的药动学过程.方法:生物样本经乙酸乙酯萃取后,用LC-MS法测定长春瑞滨浓度.色谱柱为Shimadzu ODS(150 mm...
Effect of antofloxacin, a novel fluoroquinolone, on pharmacokinetics of theophylline in humans:possi
[会议论文] 作者：Liu Li,Pan Xian,Liu Xiao-Dong,Xie L,Wang Guang-Ji,
来源：第二届“定量药理与新药评价”国际学术会议 年份：2010
AIM: This study evaluated the pharmacokinetic interaction between theophylline and antofloxacin in vivo and in vitro.METHODS: A randomized, 5-day treatment and 3-way crossover design was documented in...
Genistein enhances amyloid-β 42 clearance across blood-brain barrier by inducing P-glycoprotein in v
[会议论文] 作者：NIU Fang,ZHOU Fang,WU Xiao-lan,ZHANG Jing-wei,WANG Guang-ji,
来源：第十届全国药物和化学异物代谢学术会议暨第三届国际ISSX/CSSX联合学术会议 年份：2012
Objective Genistein is a good candidate as an alternative to estrogen replacement therapy for Aizheimer disease (AD)because of the effects in ameliorating learning or memory deficits of AD without inc...
Genistein Enhances Amyloid-β 42 Clearance across Blood-Brain Barrier by Inducing P-Glycoprotein in v
[会议论文] 作者：NIU Fang,ZHOU Fang,WU Xiao-lan,ZHANG Jing-wei,WANG Guang-ji,
来源：江苏省药理学会青年工作委员会成立大会暨药理学科青年科技创新学术研讨会 年份：2013
...
Synergetic effect of 20(S)-ginsenoside Rh2 on ciprofloxacin: investigation on the function of efflux
[会议论文] 作者：SUN Yuan,ZHOU Fang,ZHA Wei-bin,ZHANG Jing-wei,WANG Guang-ji,
来源：第十届全国药物和化学异物代谢学术会议暨第三届国际ISSX/CSSX联合学术会议 年份：2012
Objective Bacterial drag resistance caused by effiux pump remains problematic.Our previous study showed that 20 (S)-ginsenoside Rh2 (20 (S)-Rh2) reversed multidrug resistance (MDR) in MCF-7 cells by i...
Induction of retinoid metabolism related cytochrome P450 by Chrysanthemum morifolium Ramat extract i
[会议论文] 作者：Wang Ping,Pan Xian,Liu Xiao-dong,Xie Lin,Wang Guang-ji,Guo Hao,
来源：第二届“定量药理与新药评价”国际学术会议 年份：2010
Chrysanthemum, a traditional Chinese medicine, shows various pharmacological activities including anti-inflammatory, anti-oxidative and free radical scavenging.It has long been extensively used for re...
Development and validation of an improved LC-MS/MS method for simultaneous quantitation of metformin
[会议论文] 作者：ZHANG Xue-yuan,PENG Ying,SUN Jian-guo,WAN Ping,YIN Li-fang,WANG Guang-ji,
来源：第十届全国药物和化学异物代谢学术会议暨第三届国际ISSX/CSSX联合学术会议 年份：2012
Objective To support the pharmacokinetic study of metformin (MET) hydroehloride/pioglitazone (PIO) hydroehloride tablet, an LC-MS/MS method was developed for the simultaneous determination of MET and...
Effects of diammonium glycyrrhizinate on hepatic and intestinal UDP-Glucuronosyltransferases in rats
[期刊论文] 作者：LI Fei-Yan,XIE Hao,WENG Lin,WANG Hong,CAO Li-Juan,HAO Hai-Ping,WANG Guang-Ji,,
来源：Chinese Journal of Natural Medicines 年份：2016
Glycyrrhizin is a major bioactive component of liquorice, which exerts multiple biochemical and pharmacological activities and is frequently used in combination...
The Pharmacokinetic-Pharmacodynamic Model of Azithromycin for Lipopolysaccharide-Induced Depressive-
[会议论文] 作者：HAO Kun,QI Qu,HAO Hai-Ping,WANG Guang-Ji,CHEN Yuan-Cheng,LIANG Yan,XIE Lin,
来源：第十届全国药物和化学异物代谢学术会议暨第三届国际ISSX/CSSX联合学术会议 年份：2012
A mechanism-based model was developed to describe the time course of lipopolysaccharide-induced depressive-like behavior and azithromycin pharmacodynarnics in mice.The lipopolysacchatide-induced disea...
Appropriate choice of collision-induced dissociation energy for qualitative analysis of notoginsenos
[期刊论文] 作者：WANG Guang-Ji,FU Han-Xu,XIAO Jing-Cheng,YE Wei,RAO Tai,SHAO Yu-Hao,KANG Dian,
来源：中国天然药物 年份：2016
...
Pharmacodynamics and potential synergistic effects of Mai-Luo-Ning injection on cardiovascular prote
[期刊论文] 作者：WU Liang,SHEN Han-Yuan,WU Yu-Zheng,YU Xiao-Yi,WANG Hong,CHENG Xue-Fang,WANG Guang-Ji,
来源：中国天然药物 年份：2015
...
Pharmacodynamics and potential synergistic effects of Mai-Luo-Ning injection on cardiovascular prote
[期刊论文] 作者：WU Liang,SHEN Han-Yuan,WU Yu-Zheng,YU Xiao-Yi,WANG Hong,CHENG Xue-Fang,WANG Guang-Ji,HAO Hai-Ping,,
来源：Chinese Journal of Natural Medicines 年份：2015
As a computer-assisted approach, molecular docking has been universally applied in drug research and development and plays an important role in the investigatio...
Appropriate choice of collision-induced dissociation energy for qualitative analysis of notoginsenos
[期刊论文] 作者：WANG Guang-Ji,FU Han-Xu,XIAO Jing-Cheng,YE Wei,RAO Tai,SHAO Yu-Hao,KANG Dian,XIE Lin,LIANG Yan,,
来源：Chinese Journal of Natural Medicines 年份：2016
Liquid chromatography hybrid ion trap/time-of-flight mass spectrometry possesses both the MS~n ability of ion trap and the excellent resolution of a time-of-fli...
A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inh
[期刊论文] 作者：WANG Yu-Xin,DU Yi,LIU Xia-Fei,YANG Fang-Xiu,WU Xiao,TAN Li,LU Yi-Hong,ZHANG Jing-Wei,ZHOU Fang,WANG Guang-Ji,
来源：中国天然药物 年份：2019
We investigated the potential hepatoprotective effect of Radix Bupleuri (RB) by inducing acute liver injury (ALI) in an animal model using acetaminophen (APAP) after pretreatment with RB aqueous extract for three consecutive days.Compared t......
Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoho
[期刊论文] 作者：,GE Chao-Liang,GUO Yi-Tong,ZHANG Peng-Fei,YAN Ting-Ting,ZHOU Ji-Yu,HE Qing-Xian,CHENG Long-Hao,WANG Guang-Ji,
来源：中国天然药物 年份：2021
Nonalcoholic fatty liver disease (NAFLD) is regarded as the most common liver disease with no approved therapeutic drug currently.Silymarin,an extract from the...
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