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Sulfation of Melatonin: enzymatic characterization, differences of genders,organs and species, and b
[会议论文] 作者：Xiangge Tian,Xiaokui Huo,Baojian Wu,Xiaobo Wang,Chao Wang,Xiaochi Ma,
来源：2015第11届全国药物和化学异物代谢学术会议 年份：2015
Exogenous melatonin (Mel) is widely used in clinic for multiple therapeutic purposes.In metabolism pathways of Mel,6-hydroxymelatonin-sulfate (S-O-Mel) and N-acetylserotonin sulfate (S-NAS) are the mo...
A first highly selective probe for SULT2A1 activityin measurement of different biological samples ba
[会议论文] 作者：Weiru Jiang,Xiangge Tian,Xiaokui Huo,Chengpeng Sun,Chao Wang,Xiaochi Ma,
来源：第二届《药学学报》药学前沿论坛 年份：2016
Human cytosolsulfotransferase 2A1(SULT2A1)is a major metabolicenzyme isoform that mediates a sulfation reaction,which is a significant detoxification pathway for some endogenous and exogenous substrat...
Characterize the phase Ⅰ and Ⅱ metabolism of AKBA and KBA in human, species differences, bioactivity
[会议论文] 作者：Chao Wang,Min Xu,Xiaokui nuo,Yonglei Cui,Xiangge Tian,Weiru Jiang,Xiaochi Ma,
来源：2015第11届全国药物和化学异物代谢学术会议 年份：2015
Objective Boswellia serrata was widely used in traditional medicine as an anti-inflammatory agent, 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-b...
Characterize the phase Ⅰ and Ⅱ metabolism of AKBA and KBA in human, species differences, bioactivity
[会议论文] 作者：Yonglei Cui,Weiru Jiang,Min Xu,Chao Wang,Xiaokui nuo,Xiangge Tian,Xiaochi Ma,
来源：2015第11届全国药物和化学异物代谢学术会议 年份：2015
Objective Boswellia serrata was widely used in traditional medicine as an anti-inflammatory agent, 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) were the most potent BAs....
[期刊论文] 作者：Lei Feng,Zhenhao Tian,Ming Zhang,Xin He,Xiangge Tian,Zhenlong Yu,Xiaochi Ma,Chao Wang,
来源：中国化学快报（英文版） 年份：2021
A NIR fluorescent probe (DDAA) derived from fluorophore DDAO with alanine as the recognition group was developed for sensing aminopeptidase N (APN) in gut microbiota.Using DDAA as the real-time guidance tool for the fluorescence imaging of ......
Herb-drug interaction prediction based on the quantitative structure-activity relationship (QSAR) of
[会议论文] 作者：Min Xu,Xiangge Tian,Peipei Dong,Xiaokui Huo,Chao Wang,Baojing Zhang,Shanshan Huang,Sa Deng,Xiaochi Ma,
来源：2015第11届全国药物和化学异物代谢学术会议 年份：2015
Object: The wide application of herbal medicines containing steroids and their saponins has resulted in the high risk of herb-drug interactions (HDIs)....
A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in liv
[期刊论文] 作者：Mingyue Zhu,Zhenhao Tian,Lingling Jin,Xiaokui Huo,Chao Wang,Jingnan Cui,Yan Tian,Xiangge Tian,Lei Feng,
来源：化学科学与工程前沿 年份：2022
Uridine diphosphate(UDP)-glucuronosyl-transferases(UGTs)are enzymes involved in the biotrans-formation of important endogenous compounds such as steroids,bile acids,and hormones as well as exogenous substances including drugs,environmental ......
,Correlation analysis between the chemical contents and bioactivity for the quality control of Alism
[期刊论文] 作者：Xiaoxv Gao,Chengpeng Sun,Zhenglong Yu,Jian Cang,Xiangge Tian,Xiaokui Huo,Lei Feng,Xinguang Liu,Chao Wang,
来源：药学学报（英文版） 年份：2018
In order to clarify regions of production and to discriminate processing methods,quantitative and qualitative analyses for saccharides and terpenes in 35 batche...
[会议论文] 作者：Yonglei Cui,Jing Ning,Chao Wang,Peipei Dong,Guangbo Ge,Xiangge Tian,Jie Hou,Xiaokui Huo,Baojing Zhang,
来源：2015第11届全国药物和化学异物代谢学术会议 年份：2015
Objective Bufadienolides are a major class ofbioactive compounds derived from amphibian skin secretion.This work aim to characterize the sulfation of bufadienolides including conjugation position, the...
[期刊论文] 作者：Xiangge Tian,Chao Wang,Peipei Dong,Yue An,Xinyu Zhao,Weiru Jiang,Gang Wang,Jie Hou,Lei Feng,Yan Wang,,
来源：药学学报（英文版） 年份：2018
Human cytosolic sulfotransferase 2A1 (SULT2A1) is an important phase Ⅱ metabolic enzyme.The detection of SULT2A1 is helpful for the functional characterization...
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