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[会议论文] 作者：LI Hua,ZHUANG Xiao-mei,
来源：2015年第一届药代动力学朝阳论坛 年份：2015
Metabolizing enzymes and transporters play important roles in clearance and disposition of xenobiotics.Metabolizing enzymes mediated metabolism of xenobioti...
Inhibition of P-glycoprotein gene expression and function enhances triptolide-induced hepatotoxicity
[会议论文] 作者：KONG Ling-lei,ZHUANG Xiao-mei,LI Hua,
来源：2015年第一届药代动力学朝阳论坛 年份：2015
Triptolide, a major active ingredient of Tripterygium wilfordii Hook F., has been widely used for treatment of autoimmune disease in China.However, narrow therapeutic window and severe hepatotoxicity...
Potential for herb-drug interactions associated with furanocoumarin compounds, the major bioactive c
[会议论文] 作者：CHEN Lin,ZHUANG Xiao-mei,KONG Ling-lei,SHEN Guo-lin,GAO Yan,LI Hua,
来源：2015年第一届药代动力学朝阳论坛 年份：2015
Herbal medicinal products belong to a main part of complementary and alternative medicine and have worldwide using integrated with conventional medicines for treatment.However, the increasing risk of...
[期刊论文] 作者：ZHUANG Xiao-Mei,CHEN Lin,TAN Yan,YANG Hai-Ying,LU Chuang,GAO Yue,LI Hua,,
来源：Chinese Journal of Natural Medicines 年份：2017
Ferulic acid(FA) is an active component of herbal medicines. One of the best documented activities of FA is its antioxidant property. Moreover, FA exerts antial...
[会议论文] 作者：XIAO Wei-bin,ZHUANG Xiao-mei,RANG Xiao-rong,SNEN Guolin,DAI Yu-qin,LI Hua,ZHU Ming-she,
来源：2015年第一届药代动力学朝阳论坛 年份：2015
Drug ADME experiment in humans is a pivotal drug metabolism study in support of drug development and registration.Human ADME study provides information on the exposure of drug related components, excr...
Application of physiologically based pharmacokinetic model to assess xenobiotic disposition in human
[会议论文] 作者：ZHUANG Xiao-Mei,XIAO Wei-Bin,ZHONG Yu-Huan,LU Fei,LU Chuang,ZHANG Zhen-qing,LI Hua,
来源：2015年第一届药代动力学朝阳论坛 年份：2015
Accurate prediction of human pharmacokinetics from preclinical in vivo and in vitro data remains a critical goal in the drug discovery and development process to minimize risk during first-in-human st...
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