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Discovery of Novel Monocarbonyl Ligustrazine-Curcumin Hybrids as Potential Thioredoxin Reductase Inh
[会议论文] 作者：Zhangjian HUANG,Yong AI,Yihua ZHANG,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
The elevation of oxidative stress preferentially in cancer cells by inhibiting thioredoxin reductase(TrxR)and/or enhancing reactive oxygen species(ROS)has emerged as an effective strategy for selectiv...
[会议论文] 作者：Jianbing Wu,Yihua Zhang,Zhangjian Huang,
来源：2016年长三角药物化学研讨会 年份：2016
Evidence is accumulating that high levels of nitric oxide (NO) could act as a cytotoxic and apoptosis-inducing agent against tumor cells.[1]Diazeniumdiolates derived from secondary amines usually act...
[会议论文] 作者：Jingchao LIU,Wenlong LI,Zhangjian HUANG,Sixun PENG,Yihua ZHANG,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Rosiglitazone is clinically used to treat insulin resistance.However,its long-term administration will increase the incidence of cardiovascular side effects.[1] Given the beneficial effects of nitric...
Synthesis and Biological Evaluation of GST-π-Based Novel NO-Donating CDDO Derivatives as Potential A
[会议论文] 作者：Fenghua KANG,Yong AI,Zhangjian HUANG,Sixun PENG,Yihua ZHANG,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
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Design,Synthesis and Biological Evaluation of Nitric oxide/Hydrogen Sulfide-Donating Hybrids of 3-n-
[会议论文] 作者：Wei YIN,Jiangen FANG,Zhangjian HUANG,Sixun PENG,Yihua ZHANG,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
...
Identification of Nitric Oxide-Releasing Derivatives of Oleanolic Acid as Potential Anti-Colon Cance
[会议论文] 作者：Yu ZOU,Junjie FU,Zhangjian HUANG,Huibin ZHANG,and Yihua ZHANG,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
The overexpressed GSTπ isozyme in tumor cells was regarded as targets for the design of anti-cancer agents.Herein,a group of GSTπ-based nitric oxide(NO)-releasing derivatives of oleanolic acid(OA)(1–9...
Design and synthesis of novel piperlongumine derivatives for intervention of colon cells proliferati
[会议论文] 作者：Yu Zou,Chang Yan,Zhangjian Huang,Huibin Zhang,Yihua Zhang,
来源：2016年长三角药物化学研讨会 年份：2016
...
[期刊论文] 作者：Zhuangzhuang Liang,Yunjie Wang,Qinghong Shang,Shengbin Zhang,Cunfang Wang,Mingmin Ni,Dalei Wu,Zhangjian Huang,
来源：药学学报（英文版） 年份：2021
Blood-brain barrier(BBB)damage after ischemia significantly influences stroke outcome.Com-pound LFHP-1c was previously discovered with neuroprotective role in stroke model,but its mechanism of action on protection of BBB disruption after st......
[期刊论文] 作者：Jintong Du,Jing Guo,Dongwei Kang,Zhihong Li,Guan Wang,Jianbing Wu,Zhen Zhang,Hao Fang,Xuben Hou,Zhangjian Huang,
来源：中国化学快报（英文版） 年份：2020
Great success has been witnessed in last decades,some new techniques and strategies have been widely used in drug discovery.In this roadmap,several representati...
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