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Polarity of TRP channel rectification: mutations of a key pore helix residue of TRPA1 reverse its vo
[会议论文] 作者：Zhaobing Gao,
来源：The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 年份：2014
...
Polarity of TRP channel rectification mutations of a key pore helix residue of TRPA1 reverse its vol
[会议论文] 作者：Zhaobing Gao,
来源：The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 年份：2014
Transient Receptor Potential A1 (TRPA1) is implicated in somatosensory processing and pathological pain sensation.Although not strictly voltage-gated, ionic cur...
[会议论文] 作者：Zhaobing Gao,
来源：第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis 年份：2016
KCNQ channels are proven anti-epileptic drug targets.We took advantage of two strategies to identify novel KCNQ activators.First,a library including 800,000 compounds was screened by a traditional hig...
[会议论文] 作者：Zhaobing Gao,Min Li,
来源：The 3rd Ion Channel Conference: Ion channels-Structure, Func 年份：2011
Voltage-gated potassium channels play a critical role in controlling membrane excitability.Like a typical voltage-gated ion channels (Kv), KCNQ channels undergo closed to open transitions by sensing t...
[会议论文] 作者：Zhaobing GAO,Min LI,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
KCNQ potassium channels play a critical role in controlling membrane excitability.Like a typical voltagegated ion channels (Kv), KCNQ channels undergo closed to open transitions by sensing transmembra...
Molecular structural basis of TRPA1 channel rectification A singe residue in the pore region determi
[会议论文] 作者：Xia Wan,Xueqin Chen,Zhaobing Gao,
来源：The 9th Chinese Symposium on Calcium Signalling(第九届全国钙信号和细胞功 年份：2012
...
hERG automated electrophysiological assays using high throughput IonWorks Barracuda primary and high
[会议论文] 作者：XueQin Chen,JinFeng Yue,ZhaoBing Gao,
来源：第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis 年份：2016
Drug-induced prolongation of the QT interval via block of cardiac ion channel coded by human ether-à-gogo-related gene(hERG,alternative nomenclature KCNH2)is a major safety concern in the process of d...
Molecular structural basis of TRPA1 channel rectification A singe residue in the pore region determi
[会议论文] 作者：Xia Wan,Xueqin Chen,Zhaobing Gao,
来源：The 9th Chinese Symposium on Calcium Signalling(第九届全国钙信号和细胞功 年份：2012
...
[会议论文] 作者：Pingzheng Zhou,Haibo Yu,Min Gu,Fa-jun Nan,Zhaobing Gao,Min Li,
来源：上海市细胞生物学学会第十届CST细胞生物学青年论坛 年份：2014
Pharmacological augmentation of neuronal KCNQ muscarinic (M) currents by drugs such as retigabine (RTG) represents a first-in-class therapeutic to treat certain...
[会议论文] 作者：Bingqing Xia,Sui Fang,Xueqin Chen,Hong Hu,Peiyuan Chen,Huayi Wang,Zhaobing Gao,
来源：第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis 年份：2016
The mixed lineage kinase domain-like(MLKL)protein is a key factor in tumor necrosis factor-induced necroptosis.Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane di...
A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2
[会议论文] 作者：Huaiyu Yang,Zhaobing Gao,Ping Li,Kunqian Yu,Ye Yu,Tian-Le Xu,Min Li,Hualiang Jiang,
来源：The 4th International Ion Channel Conference(第四届国际离子通道会议) 年份：2013
Biological membranes, including both plasma membrane and those compartmenting subcellular organelle, have provided the basis of bioelectrical gradients.Hence, almost all membrane proteins function at...
High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer’s di
[期刊论文] 作者：Xiaochuan Zhang,Xianzhen Yin,Jingjing Zhang,Anan Li,Hui Gong,Qingming Luo,Haiyan Zhang,Zhaobing Gao,Hualiang,
来源：国家科学评论（英文版） 年份：2019
Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer’s disease (AD).However,systematic compa...
[会议论文] 作者：Ping Li,Min Li,Zhuxi Chen,Haiyan Xu,Haifeng Sun,Hao Li,Hong Liu,Huaiyu Yang,Zhaobing Gao,Hualiang Jiang,
来源：上海市细胞生物学学会第十届CST细胞生物学青年论坛 年份：2014
Voltage-gated potassium (Kv) channels derive their voltage sensitivity from movement of gating charges in voltage-sensor domains (VSDs)....
[会议论文] 作者：Ping Li,Zhuxi Chen,Haiyan Xu,Haifeng Sun,Hao Li,Hong Liu,Huaiyu Yang,Zhaobing Gao,Hualiang Jiang,Fang,
来源：8th IUPAP International Conference on Biological Physics(第八届 年份：2014
...
[会议论文] 作者：Ping Li,Zhuxi Chen,Fang Bai,Haiyan Xu,Haifeng Sun,Hao Li,Hong Liu,Huaiyu Yang,Zhaobing Gao,Min Li,Hualiang,
来源：8th IUPAP International Conference on Biological Physics(第八届 年份：2014
Voltage-gated potassium (Kv) channels derive their voltage sensitivity from the movement of gating charges in voltage-sensor domains (VSDs).The gating charges t...
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