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[会议论文] 作者：Zhe-Sheng Chen,
来源：2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2012
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Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated
[会议论文] 作者：Zhe-Sheng Chen,De-Shen Wang,Dong-Hua Yang,Rui-Hua Xu,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
ABCG2 is a potential biomarker causing multidrug resistance (MDR) in Non-Small Cell Lung Cancer (NSCLC).We conducted this study to investigate whether Icoti...
Recent advances regarding the role of ABC subfamily C member 10(ABCC10) in the efflux of antitumor d
[期刊论文] 作者：Rishil J.Kathawala,Yi-Jun Wang,Charles R.Ashby Jr,Zhe-Sheng Chen,,
来源：Chinese Journal of Cancer 年份：2014
ABCC10,also known as multidrug-resistant protein 7(MRP7),is the tenth member of the C subfamily of the ATP-binding cassette(ABC) superfamily.ABCC10 mediates mul...
[期刊论文] 作者：Guan-Nan Zhang,Charles R.Ashby Jr.,Yun-Kai Zhang,Zhe-Sheng Chen,Huiqin Guo,,
来源：Chinese Journal of Cancer 年份：2015
Multidrug resistance(MDR), deined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, signiicantly limits the eica...
Synergistic antitumor activity of regorafenib and lapatinib in preclinical models of human colorecta
[会议论文] 作者：Wen-Ji Zhang,Meng-Ning Wei,Yao Chen,Dong-Hua Yang,Zhe-Sheng Chen,Zhi Shi,
来源：2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2016
Regorafenib significantly prolongs overall survival in patients with metastatic colorectal cancer(mCRC),but the overall clinical efficacy of regorafenib remains quite limited.Combination chemotherapy...
[会议论文] 作者：Zhe-Sheng Chen,De-Shen Wang,Hui Zhang,Amit Tiwari,Atish Patel,Zhi Shi,
来源：2014第七届世界癌症大会 年份：2014
We found that tyrosine kinase inhibitors (TKIs) such as erlotinib, lapatinib, nilotinib, sunitinib, tandutinib, and icotinib could reverse ATP-binding cassette (ABC) transporter-mediated multidrug res...
Discovery of novel urea-indole derivatives as reversal agents against ABCG2-mediated drug resistance
[会议论文] 作者：Gao-Jie Ye,Chao-Yun Cai,Yu-qi Yang,Zhe-Sheng Chen,Zhuo-Xun Wu,Bo Wang,
来源：第十一届全国化学生物学学术会议 年份：2019
Multidrug resistance is characterized by the resistance of cancer cells to structurally unrelated anticancer drugs....
Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin an
[期刊论文] 作者：Jason D.Whitt,Adam B.Keeton,Bernard D.Gary,Larry A.Sklar,Kamlesh Sodani,Zhe-Sheng Chen,Gary A.Piazza,,
来源：The Journal of Biomedical Research 年份：2016
ATP-binding cassette(ABC) transporters ABCC1(MRP1),ABCB1(P-gp),and ABCG2(BCRP) contribute to chemotherapy failure.The primary goals of this study were to charac...
[期刊论文] 作者：Ying-Jie Li,Yu-He Lei,Nan Yao,Chen-Ran Wang,Nan Hu,Wen-Cai Ye,Dong-Mei Zhang,Zhe-Sheng Chen,,
来源：Chinese Journal of Cancer 年份：2017
Multidrug resistance(MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor recurrence.Therefore, combatting MDR is an im...
Repurposing FDA-approved drugs for SARS- CoV-2 through an ELISA-based screening for the inhibition o
[期刊论文] 作者：Wenyu Fu,Yujianan Chen,Kaidi Wang,Aubryanna Hettinghouse,Wenhuo Hu,Jing-Quan Wang,Zi-Ning Lei,Zhe-Sheng Chen,
来源：蛋白质与细胞:英文版 年份：2021
Dear Editor,The ongoing coronavirus disease 2019(COVID-19)global pandemic is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which instigates severe and often fatal symptoms.As of September 4th,2020......
Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of
[期刊论文] 作者：Wenyu Fu,Yujianan Chen,Kaidi Wang,Aubryanna Hettinghouse,Wenhuo Hu,Jing-Quan Wang,Zi-Ning Lei,Zhe-Sheng Chen,
来源：蛋白质与细胞 年份：2004
Dear Editor,rnThe ongoing coronavirus disease 2019(COVID-19)global pandemic is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2(SAR...
[期刊论文] 作者：Chris Le,Liwu Fu,Zhe-Sheng Chen,,
来源：Acta Pharmaceutica Sinica B 年份：2017
Arsenic trioxide(ATO) is used as a chemotherapeutic agent for the treatment of acute promyelocytic leukemia. However, increasing drug resistance is reducing its...
[期刊论文] 作者：Suneet Shukla,Yun-Kai Zhang,Saeed Alqahtani,Amal Kaddoumi,Suresh V Ambudkar,Charles R Ashby Jr,Zhe-Sheng Chen,
来源：Chinese Journal of Cancer 年份：2015
Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived...
Neratinib (HKI-272) Reverses ABCB 1-Mediated Chemotherapeutic Drug Resistance in Vitro,in Vivo and e
[会议论文] 作者：Xiao-qin Zhao,Suresh V.Ambudkar,Zhe-Sheng Chen,Li-wu Fu,Jing-dun Xie,Xing-gui Chen,Hong May Sim,Xu Zhang,
来源：2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2012
Neratinib (HIK-272),an irreversible inhibitor of EGFR and Her-2,is in phase Ⅲ clinical trials for patients with Her-2-positive locally advanced or metastatic breast cancer.The objective of this study...
The epigallocatechin gallate derivative Y6 reverses drug resistance mediated by the ABCB1 transporte
[期刊论文] 作者：Yingfang Fan,Yunkai Zhang,Zhenguang Huang,Xiaohui Li,Yuangang Su,Lijuan Liao,Yu-An Xie,Donghua Yang,Zhe-Sheng Chen,
来源：药学学报（英文版） 年份：2019
Previously,we reported that Y6,a new epigallocatechin gallate derivative,is efficacious in reversing doxorubicin (DOX)-mediated resistance in hepatocellular car...
β-catenin/p300 signaling activation by CBP blockade induces cell senescence in wild-type or T315I-mu
[会议论文] 作者：Chen,Xiaodong Su,Xingping WU,Qian-Qian Han,Zhen Chen,Zhi Shi,Kenneth Kin Wah To,Brian J.Druker,Zhe-Sheng Chen,
来源：2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2016
Chronic myeloid leukemia(CML)is a clonal malignant disorder of pluripotent hematopoietic stem cells(HSCs)characterized by the formation of the novel breakpoint cluster region-Abelson tyrosine kinase(B...
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