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Prediction of First-in-Human Dose of CPRC1 Using Allometric Scaling, IVIVE and PK/PD Modeling Method
[会议论文] 作者：Yang Liu,Dongyang Liu,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Diabetes mellitus is one of the most common chronic disease in the world, CPRC 1 is a novel dipeptidylpeptidase-Ⅳ(DPP-4) inhibitor which was proposed to control hyperglycemia in patients with type 2 d...
Predicting whole blood concentrations of zonisamide in human using a physiologically based pharmacok
[会议论文] 作者：Xin Zheng,Kairui Feng,Pei Hu,Ji Jiang,Jun Shi,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium 年份：2013
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Development and validation a PBPK model to predict age-dependent PK for Chinese subjects-a case stud
[会议论文] 作者：Hongyun Wang,Xia Chen,Jun Shi,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Aim:Todevelop and validate a general physiologicallybased pharmacokinetic (PBPK) model for hepatic pathway in Chinese adults at various ages, and to evaluate it with midazolam (substrate of CYP3A4) as...
[会议论文] 作者：Jia Chen,Dongyang Liu,Qian Zhao,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:Icotinib is a potent small-molecule inhibitor of epidermal growth factor receptor (EGFR)-tyrosine kinase (TKI), which was designed for the treatment of non-small cell lung cancer (NSCLC).It...
A semi-mechanistic population pharmacokinetic model describing the time-dependent kinetics of Red Bl
[会议论文] 作者：Kairui Feng,Xin Zheng,Wenyuan Qi,Pei Hu,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background: XQ (Carfree, Nanjing, China), a new chemical entity that possesses pharmacological activity on PlateletActivating Factor (PAF).XQ was approved into phase Ⅰ evaluation for treatment of isch...
A Mechanistic Pharmacokinetic-Pharmacodynamic Model for the Effect of Esomeprazole in Healthy Subjec
[会议论文] 作者：Dongyang Liu,Hong Yang,Jiaming Qian,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Esomeprazole has proved to be effective for the treatment of gastroesophogeal reflux disease (GERD) and ulcers, where intra-gastric pH value is a biomarker to indicate esomeprazole effects on these di...
Population pharmacokinetic/pharmacodynamic Modeling for Pegylated Recombinant Human Growth Hormone (
[会议论文] 作者：Xin Zheng,Tao Liu,Qian Zhao,Pei Hu,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:CPRC-Y is a pegylatedrecombinant human growth hormone (rhGH) developed with the aim of reducing serum clearance and thereby prolonging the exposure leading to once-weekly sc administration.T...
Predicting whole blood concentrations of zonisamide in human using a physiologically based pharmacok
[会议论文] 作者：Xin Zheng,Kairui Feng,Pei Hu,Jun Shi,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background:Concentration dependent Blood to plasma ratio (B/P) of zonisamide(ZNS) was observed in clinical trial, which requires measuring both plasma concentration and whole blood concentration for c...
[会议论文] 作者：Rui Chen,Dongyang Liu,Jun Shi,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:In vitro information on dextromethorphan (DXM) and the Advanced Dissolution Absorption Metabolism (ADAM) model, incorporated into PBPK simulator Simcyp(@) (v.12) were used to investigate dif...
Assessing ethnic sensitivity by simulating pharmacokinetics in virtual Caucasian and Chinese populat
[会议论文] 作者：Sheng Feng,Yumi Fukushima,Pei Hu,Conni Weber,Yongqing Wang,Jun Shi,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background and Rationale: Physiologically-based pharmacokinetics (PBPK) modelling is a key component of model-based drug development and is increasingly embraced within the industry and regulatory aut...
Quantitative Estimation of Stratum Corneum Drug Content Obtained Through Tape Stripping and Its Appl
[会议论文] 作者：Wen Zhong,Xia Chen,Qian Zhao,Ji Jiang,Tao Liu,Hong-zhong Liu,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background: Dermatopharmacokinetic (DPK) bioequivalence (BE) evaluation required assessments of stratum corneum (SC) drug content.The SC samples are normall...
Sequential Population Pharmacokinetic and Pharmacodynamic Modeling of Rivaroxaban in Adult and Elder
[会议论文] 作者：Tao Liu,Ji Jiang,Xin Zheng,Qian Zhao,Xia Zhao,Yimin Cui,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Aim:Rivaroxaban (Bayer Healthcare AG, Wuppertal, Germany), an oral, direct factor Xa (FXa) inhibitor for the prevention and treatment of thromboembolic disorders has been approved for nonvalvular atri...
[会议论文] 作者：Wen Zhong,Hong-Zhong Liu,Xin Zheng,Dong-Yang Liu,Jia Chen,Pei Hu,Jun Shi,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background: The distribution of renal function and its effect on drug elimination was not well understood in Chinese population, which impeded the clinical therapeutics for Chinese patients as well as...
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