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[期刊论文] 作者：Xuhan Zhang,Kaidi Song,Wen Yao,Xiang Wan,Juan Tong,Huilan Liu,Hanying Xu,Xin Liu,Xiaoyu Zhu,Zimin Sun,Lin,
来源： 年份：2022
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[期刊论文] 作者：Xuhan,Song Kaidi,Yao Wen,Wan Xiang,Tong Juan,Liu Huilan,Xu Hanying,Liu Xin,Zhu Xiaoyu,Sun Zimin,Yang Lin,
来源：中华医学杂志英文版 年份：2022
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[期刊论文] 作者：Diyang Zhang,Wei-Hong Sun,Ding-Kun Liu,Jie Huang,Jin-Liao Chen,Xiao-Qin Zhou,Wan-Lin Fan,Wen-Chun Zhang,Lin,
来源：遗传学报 年份：2022
Melastomataceae has abundant morphological diversity with high economic and ornamental merit in Myrtales.The phylogenetic position of Myrtales is still contested.Here,we report the chromosome-level genome assembly of Melastoma dodecandrum i......
[期刊论文] 作者：Zhitao Ying,Ting He,Shanzhao Jin,Xiaopei Wang,Wen Zheng,Ningjing Lin,Meifeng Tu,Yan Xie,Lingyan Ping,,
来源：中国癌症研究（英文版） 年份：2022
Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However......
Identification of novel loci influencing refractive error in East Asian populations using an extreme
[期刊论文] 作者：Xiaotong Han,Tianzi Liu,Xiaohu Ding,Jialin Liu,Xingyan Lin,Decai Wang,Moeen Riaz,Paul N.Baird,Zhi Xie,
来源：遗传学报 年份：2022
The global“myopia boom”has raised significant international concerns.Despite a higher myopia preva-lence in Asia,previous large-scale genome-wide association studies(GWASs)were mostly based on Eu-ropean descendants.Here,we report a GWAS o......
[期刊论文] 作者：Huang,Chen-Song Zhang,Shanxin Lu,Yunpeng Zhang,Yuanyong Huang,Zhaosu Chen,Wei Wei,Lujian Liao,Shu-Hai Lin,
来源：细胞研究（英文版） 年份：2022
The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis.Although much has been learned on how low energy status and glucose starvation activate AMPK,how AMPK activity is properly controlled in vivo is still poor......
Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung F
[期刊论文] 作者：Li-Sha Guo,Qiang-Qiang Shi,Teng-Fei Zhou,Yang Chen,Huai Zhang,Hui Cai,Zhi-Wei Xu,Shuan-Ying Yang,Hai Lin,
来源：临床与转化肝病杂志（英文版） 年份：2022
Background and Aims: We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD), and examined the association between lung function parameters and fibros......
Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migrati
[期刊论文] 作者：Wei,Shaobo Ning,Xiuyan Yang,Mingzhu Zhao,Yuran Qiu,Kun Song,Zhengtian Yu,Jianrong Xu,Xinyi Li,Houwen Lin,
来源：药学学报（英文版） 年份：2022
SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the ......
Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to h
[期刊论文] 作者：Yuhang Zhang,Qingshan Chen,Chunbao Zhang,Kun Kou,Tong Su,Lingshuang Wang,Shichen Li,Haiyang Li,Xiaoya Lin,
来源：分子植物（英文版） 年份：2022
Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combini......
[期刊论文] 作者：Yan Gao,Wei Yang,Changsong Wang,Haitao Liu,Guangping Chang,Xianxin Kang,Yunpeng Luo,Xue Du,Jiping Qi,Lin,
来源： 年份：2022
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[期刊论文] 作者：Yan,Yang Wei,Wang Changsong,Liu Haitao,Chang Guangping,Kang Xianxin,Luo Yunpeng,Du Xue,Qi Jiping,Tian Lin,
来源：中华医学杂志英文版 年份：2022
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[期刊论文] 作者：程颖,Li ZHANG,Jie HU,Donglin WANG,Chengping HU,Jianying ZHOU,Lin WU,Lejie CAO,Jiwei LIU,Helong ZHANG,Hong,
来源：中国肺癌杂志 年份：2022
背景与目的 在随机双盲的3期临床研究KEYNOTE-407中，与安慰剂联合化疗相比，帕博利珠单抗联合化疗显著改善了初治转移性鳞状非小细胞肺癌（non-small cell lung cancer, NSCLC）患者的生存结局。本研究报道了纳入K EY NOTE-407全球研究和中国扩展研究的中国患者的临床......
Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynt
[期刊论文] 作者：Chao Dou,Zhaolin Long,Shoujie Li,Dan Zhou,Ying Jin,Li Zhang,Xuan Zhang,Yanhui Zheng,Lin Li,Xiaofeng Zhu,
来源：细胞研究（英文版） 年份：2022
Methanobactins(Mbns)are a family of copper-binding peptides involved in copper uptake by methanotrophs,and are potential therapeutic agents for treating diseases characterized by disordered copper accumulation.Mbns are produced via modifica......
[期刊论文] 作者：Shiyu Wang,Yulin Wu,Youwei Zhao,Chen Zha,Shaowei Li,Zhen Zhang,Qi Zhao,Yunchao Liu,Futian Liang,Jin Lin,
来源：国家科学评论（英文版） 年份：2022
Quantum error correction is an essential ingredient for universal quantum computing.Despite tremendous experimental efforts in the study of quantum error correction,to date,there has been no demonstration in the realisation of universal qua......
[期刊论文] 作者：Junyan Han,Ning Zhang,Danying Chen,Yuhuan Gong,Guoli Li,Yaxian Kong,Lin Pu,Chen Chen,Jingyuan Liu,Qi,
来源：中国科学：生命科学（英文版） 年份：2022
Dear Editor,rnThe coronavirus disease 2019 (COVID-19) pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity.The speed of vaccine de......
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