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[会议论文] 作者：Beibei Mao,Liangren Zhang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
The mammalian target of rapamycin(mTOR)is a critical component part of the PI3K-Akt signaling pathway that plays a key role in the regulation of cellular growth and proliferation.Dysregulation of mTOR...
Comparative Analysis of Pharmacophore Features and Quantitative Structure-Activity Relationships for
[会议论文] 作者：Shuang Zhang,Xiwen Xue,Liangren Zhang,Lihe Zhang,Zhenming Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Human CD38 is a member of ADP-ribosyl cyclase family,which is a type Ⅱor type Ⅲ transmembrane glycoprotein1.CD38 can catalyzes the transformation of β-NAD+and NADP to the Ca2+-mobilizing messengers cA...
[会议论文] 作者：Yanjun Shen,Fen Pei,Hongwei Jin,Liangren Zhang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Toll-like receptor 8(TLR8)is one of the evolutionally conserved pattern recognition receptors(PRRs).TLR8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polariz...
[会议论文] 作者：Qiyao Luo,Ziyun Wang,Zhenming Liu,Liangren Zhang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Endothelial lipase(EL)has been implicated in HDL metabolism and the pathogenetic progress of atherosclerosis,and its specific inhibitors are expected to be useful for the treatment of cardiovascular d...
[会议论文] 作者：LIDAN SUN,HONGWEI JIN,ZHENJUN YANG,LIANGREN ZHANG,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Thrombin-binding DNA aptamer(TBA)can fold into an G-quadruplex structure necessary for interacting with thrombin.It is reported that incorporation the D-isothymidine(D-isoT)or unlocked nucleic acid(UN...
Integrating Pharmacophore into Membrane Molecular DynamicsSimulations to Improve Homology Modeling o
[会议论文] 作者：Mengxin Guan,Lingxiao Zeng,Hongwei Jin,Zhenming Liu,Liangren Zhang,
来源：第十三届全国计算机化学学会会议 年份：2015
Homology modeling has been applied to fill in the gap in experimental G protein-coupledreceptors(GPCRs)structure determination.However,achievement of GPCR h...
New Insights into the Chemical Druggability Prediction 1:Toward Constructing Reliable Drug and Bench
[会议论文] 作者：Jie Xia,Liangren Zhang,Jianxing Hu,Zili Jin,Zhenming Liu,
来源：第十三届全国计算机化学学会会议 年份：2015
...
New Insights into the Chemical Druggability Prediction 1:Toward Constructing Reliable Drug and Bench
[会议论文] 作者：Jianxing Hu,Zili Jin,Jie Xia,Zhenming Liu,Liangren Zhang,
来源：第十三届全国计算机化学学会会议 年份：2015
Quantitative or qualitative characterization of the drug-like features of known drugs can help medicinal chemists to select higher quality drug leads from a huge pool of compounds and to improve the e...
[会议论文] 作者：Ya CHEN,Yong TANG,Hongwei JIN,Zhenming LIU,Liangren ZHANG,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Breast cancer is one of the most common malignant tumor in women,both in the developed countries and developing countries.Triple-negative breast cancer(TNBC)refers to any breast cancer that does not e...
Design,Synthesis,and Structure-Activities Relationship Studies of α7 Nicotinic Acetylcholine Recepto
[会议论文] 作者：Qing Li,Yu Xue,Taoyi Yang,Xiaozhuo Ma,Kewei Wang,Liangren Zhang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Nicotinic acetylcholine receptors(nAChRs)are members of Cys-loop ligand gated ion channels superfamily.The α7 nAChR,a homopentamer composed of five α7 subunits,has been implicated in diseases associat...
[会议论文] 作者：Li WU,Fen PEI,Jinhao ZhANG,Junzhou WU,Mengke FENG,Yuan WANG,Hongwei JIN,Liangren ZhANG,Xinjing Tang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
A complete set of new phospate-caged photolabile nucleoside phosphoramidites were synthesized,and were then site-specifically incorporated into sense or antisense strands of a siRNA.Single caging modi...
[会议论文] 作者：Zhang Zhang,
来源：The 4th International Conference of Genomics Beyond Biologic 年份：2015
Integration of various types of omics data is critically indispensable for addressing most important and complex biological questions.In the era of big data,how...
[会议论文] 作者：Zhang Zhang,
来源：2015年第二届全国功能基因组学学术峰会 年份：2015
Integration of various types of omics data is critically indispensable for addressing mostimportant and complex biological questions....
Assessment of renal function in Nephron sparing surgery of renal tumors by diffusion weighted imagin
[会议论文] 作者：qiang wei,xiao lyn,liangren liu,lu yang,zhenhua liu,
来源：第十三届亚洲泌尿外科学会年会(UAA2015)、第二十二届全国泌尿外科学术会议(CUA2015)、第十六届全军及武警泌尿 年份：2015
...
Assessment of renal function in Nephron sparing surgery of renal tumors by diffusion weighted imagin
[会议论文] 作者：qiang wei,xiao lyn,liangren liu,lu yang,zhenhua liu,
来源：第十三届亚洲泌尿外科学会年会(UAA2015)、第二十二届全国泌尿外科学术会议(CUA2015)、第十六届全军及武警泌尿 年份：2015
To investigate the the change of functional MRI parameter before and one month after NSS.DWI MRI was used to observing the changes in microstructure, and trying to find a non-invasive, non-radioactive...
[会议论文] 作者：Zhijun Zhang,Shiwei Zhang,Yuekai Zhang,
来源：纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会 年份：2015
...
[会议论文] 作者：Shixiang Sun,Huiyong Zhang,Zhang Zhang,
来源：The 4th International Conference of Genomics Beyond Biologic 年份：2015
Codon usage bias,as a combined interplay from mutation and selection,has been intensively studied in Escherichia coli.However,codon usage analysis in an E.coli pangenome remains unexplored and the rel...
[期刊论文] 作者：Hongwu Zhang,Xiaoju Zhang,
来源：应用数学与应用物理(英文) 年份：2015
A Cauchy problem for the semi-linear elliptic equation is investigated. We use a filtering function method to define a regularization solution for this ill-pose...
[期刊论文] 作者：Jie Zhang,Wei Zhang,
来源：无线工程与技术(英文) 年份：2015
A kind of novel multi-frequency monopole antenna with sector-nested fractal is proposed and designed, which is nested with a series of similar circular sector e...
[期刊论文] 作者：Yingliang ZHANG,Jianfeng ZHANG,
来源：亚洲农业研究：英文版 年份：2015
Based on a survey of 939 farmers in Sichuan and Chongqing,this paper analyzes the influencing factors of entrepreneurial farmers’ formal financial credit deman...
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