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[会议论文] 作者:Beibei Mao,Liangren Zhang,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
The mammalian target of rapamycin(mTOR)is a critical component part of the PI3K-Akt signaling pathway that plays a key role in the regulation of cellular growth and proliferation.Dysregulation of mTOR...
[期刊论文] 作者:ZHAO LiJun,ZHANG LiangRen,LEI,
来源:中国科学:化学英文版 年份:2013
Transthyretin (TTR ) ,有 tetramer 结构的血浆蛋白质,能形成通过 tetramer 的分离和单体的错误褶层与几人的疾病联系的淀粉的纤丝。这些 amyloidogenesis 能被绑在 TTR 的中...
3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibito
[期刊论文] 作者:ZHAO LiJun,ZHANG LiangRen,LEI Ming,,
来源:Science China(Chemistry) 年份:2013
Transthyretin(TTR),a plasma protein with a tetramer structure,could form amyloid fibril associated with several human diseases through the dissociation of tetra...
Comparative Analysis of Pharmacophore Features and Quantitative Structure-Activity Relationships for
[会议论文] 作者:Shuang Zhang,Xiwen Xue,Liangren Zhang,Lihe Zhang,Zhenming Liu,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
Human CD38 is a member of ADP-ribosyl cyclase family,which is a type Ⅱor type Ⅲ transmembrane glycoprotein1.CD38 can catalyzes the transformation of β-NAD+and NADP to the Ca2+-mobilizing messengers cA...
Discovery and Identification of Agonists of Cyclic ADP-ribose Regulated Calcium Pathway Discovery an
[会议论文] 作者:Xuan Wang,Shuang Zhang,Hongwei Jin,Zhenming Liu,Liangren Zhang,Lihe Zhang,
来源:第八届国际分子模拟与信息技术应用学术会议 年份:2016
...
Discovery and Identification of Agonists of Cyclic ADP-ribose Regulated Calcium Pathway Discovery an
[会议论文] 作者:Xuan Wang,Shuang Zhang,Hongwei Jin,Zhenming Liu,Liangren Zhang,Lihe Zhang,
来源:第八届国际分子模拟与信息技术应用学术会议 年份:2016
Cyclic adenosine diphosphate ribose(cADPR) is a second messenger in the calcium signaling pathway.For elucidating its molecular mechanism to regulate calcium release,a lot of cADPR analogues have been...
[会议论文] 作者:Yanjun Shen,Fen Pei,Hongwei Jin,Liangren Zhang,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
Toll-like receptor 8(TLR8)is one of the evolutionally conserved pattern recognition receptors(PRRs).TLR8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polariz...
[会议论文] 作者:Qiyao Luo,Ziyun Wang,Zhenming Liu,Liangren Zhang,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
Endothelial lipase(EL)has been implicated in HDL metabolism and the pathogenetic progress of atherosclerosis,and its specific inhibitors are expected to be useful for the treatment of cardiovascular d...
[会议论文] 作者:LIDAN SUN,HONGWEI JIN,ZHENJUN YANG,LIANGREN ZHANG,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
Thrombin-binding DNA aptamer(TBA)can fold into an G-quadruplex structure necessary for interacting with thrombin.It is reported that incorporation the D-isothymidine(D-isoT)or unlocked nucleic acid(UN...
[会议论文] 作者:Dongying Wu,Kai Yiu Ting,Liangren Zhang,Lihe Zhang,Hon Cheung Lee,
来源:第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份:2012
Human CD38 is a dual-functional protein that acts not only as a receptor but also as a signaling enzyme,catalyzing the formation of Ca2+ messenger molecules,cyclic ADP-ribose(cADPR),ADPR and nicotinic...
Integrating Pharmacophore into Membrane Molecular DynamicsSimulations to Improve Homology Modeling o
[会议论文] 作者:Mengxin Guan,Lingxiao Zeng,Hongwei Jin,Zhenming Liu,Liangren Zhang,
来源:第十三届全国计算机化学学会会议 年份:2015
Homology modeling has been applied to fill in the gap in experimental G protein-coupledreceptors(GPCRs)structure determination.However,achievement of GPCR h...
New Insights into the Chemical Druggability Prediction 1:Toward Constructing Reliable Drug and Bench
[会议论文] 作者:Jie Xia,Liangren Zhang,Jianxing Hu,Zili Jin,Zhenming Liu,
来源:第十三届全国计算机化学学会会议 年份:2015
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[会议论文] 作者:Lingxiao Zeng,Mengxin Guan,Hongwei Jin,Zhenming Liu,Liangren Zhang,
来源:第八届国际分子模拟与信息技术应用学术会议 年份:2016
Homology modeling has been applied to fill in the gap in experimental G protein-coupled receptors structure determination.However,achievement of G protein-coupled receptors homology models with ligand...
New Insights into the Chemical Druggability Prediction 1:Toward Constructing Reliable Drug and Bench
[会议论文] 作者:Jianxing Hu,Zili Jin,Jie Xia,Zhenming Liu,Liangren Zhang,
来源:第十三届全国计算机化学学会会议 年份:2015
Quantitative or qualitative characterization of the drug-like features of known drugs can help medicinal chemists to select higher quality drug leads from a huge pool of compounds and to improve the e...
[会议论文] 作者:Junyong Lai,Xin Zhou,Jianxing Hu,Liangren Zhang,Zhenming Liu,
来源:2019中国化学会第十五届全国计算(机)化学学术会议 年份:2019
Natural product has long been used in the medical field.As an important source of new drugs,natural product remains essential to the pharmaceutical industry....
[会议论文] 作者:Ya CHEN,Yong TANG,Hongwei JIN,Zhenming LIU,Liangren ZHANG,
来源:2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份:2015
Breast cancer is one of the most common malignant tumor in women,both in the developed countries and developing countries.Triple-negative breast cancer(TNBC)refers to any breast cancer that does not e...
Comparison and discovery of potential non-covalent CD38 inhibitors by virtual screening strategy bas
[会议论文] 作者:Xiwen Xue,Wenjie Zhu,Liangren Zhang,Yongjuan Zhao,Zhenming Liu,
来源:第八届国际分子模拟与信息技术应用学术会议 年份:2016
As a type Ⅱ or Ⅲ transmembrane glycoprotein,human CD38 is ubiquitously expressed in all mammalian tissues.CD38 is a multi-functional enzyme and a member of the ADP-ribosyl cyclase family,and it cataly...
[会议论文] 作者:Delin Pan,Yue Chen,Chen Tang,Zhu Guan,Liangren Zhang,Zhenjun Yang,Lihe Zhang,
来源:第三届中国小核酸技术与应用学术会议 年份:2011
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[会议论文] 作者:Jie Xia,Terry-Elinor Reid,Song Wu,Liangren Zhang,Xiang Simon Wang,
来源:第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份:2018
Chemokine receptors(CRs)have long been druggable targets for the treatment of inflammatory diseases and HIV-1 infection.As a powerful technique,virtual screening(VS)has been widely applied to identify...
An Unbiased Method To Build Benchmarking Sets for Ligand-Based Virtual Screening and its Application
[会议论文] 作者:Jie Xia,Hongwei Jin,Zhenming Liu,Liangren Zhang,Xiang Simon Wang,
来源:第七届国际分子模拟与信息技术应用学术会议 年份:2014
Benchmarking data sets have become common in recent years for the purpose of virtual screening, though the main focus had been placed on the structure-based virtual screening (SBVS) approaches.Due to...
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