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SAF-189s,a potent new-generation ROS1 inhibitor,is active against crizotinib-resistant ROS1 mutant-d
[期刊论文] 作者：De-qiao Sun,Xia Peng,Ying-lei Gao,Yan-fen Fang,Xing-dong Zhao,Wei-bo Wang,Jian Ding,Mei-yu Geng,Jing Ai,
来源：中国药理学报（英文版） 年份：2021
The ROS1 fusion kinase is an attractive antitumor target.Though with significant clinical efficacy,the well-known first-generation ROS1 inhibitor(ROS1 i)crizotinib inevitably developed acquired resistance due to secondary point mutations in......
An advanced low-cost cathode composed of graphene-coated Na2.4Fe1.8(SO4)3 nanograins in a 3D graphen
[期刊论文] 作者：Yongjin Fang,Qi Liu,Xiangming Feng,Weihua Chen,Xinping Ai,Liguang Wang,Liang Wang,Zhiyuan Ma,Yang Ren,
来源：能源化学 年份：2021
Iron-based electrodes have attracted great attention for sodium storage because of the distinct cost effec-tiveness.However,exploring suitable iron-based electr...
Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipos
[期刊论文] 作者：Chenji Ye,Jinjie Duan,Xuejiao Zhang,Liu Yao,Yayue Song,Guangyan Wang,Qi Li,Biqing Wang,Ding Ai,Chunjiong,
来源：中国科学：生命科学（英文版） 年份：2021
Targeting the white-to-brown fat conversion is important for developing potential strategies to counteract metabolic diseases;yet the mechanisms are not fully u...
[期刊论文] 作者：Wen-Si Ai,Jie Liu,Qian Feng,Peng-Fei Zhai,Pei-Pei Hu,Jian Zeng,Sheng-Xia Zhang,Zong-Zhen Li,Li Liu,Xiao-Yu,
来源：中国物理B（英文版） 年份：2021
The electrical characteristics and microstructures of β-Ga2O3 Schottky barrier diode (SBD) devices irradiated with swift heavy ions (2096 MeV Ta ions) have bee...
Circumventing chemo-mechanical failure of Sn foil battery anode by grain refinement and elaborate po
[期刊论文] 作者：Shuibin Tu,Xin Ai,Xiancheng Wang,Siwei Gui,Zhao Cai,Renming Zhan,Yuchen Tan,Weiwei Liu,Hui Yang,Chenhui,
来源：能源化学 年份：2021
Tin(Sn)metal foil is a promising anode for next-generation high-energy-density lithium-ion batteries(LIBs)due to its high capacity and easy processibility.However,the pristine Sn foil anode suffers nonuni-form alloying/dealloying reaction w......
Solution-Processed Transparent Conducting Electrodes for Flexible Organic Solar Cells with 16.61％ Ef
[期刊论文] 作者：Juanyong Wan,Yonggao Xia,Junfeng Fang,Zhiguo Zhang,Bingang Xu,Jinzhao Wang,Ling Ai,Weijie Song,Kwun Nam,
来源：纳微快报（英文） 年份：2021
Nonfullerene organic solar cells (OSCs) have achieved break-through with pushing the Efficiency exceeding 17％. While this shed light on OSC commercialization, hi...
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro a
[期刊论文] 作者：Jun Fan,Yang Dai,Yin-chun Ji,Yi-ming Sun,Xia Peng,Lan-lan Li,Yu-ming Wang,Wen-hu Duan,Jian Ding,Jing Ai,
来源：中国药理学报（英文版） 年份：2021
Fibroblast growth factor receptor (FGFR) is a promising anticancer target.Currently,most FGFR inhibitors lack sufficient selectivity and have nonnegligible activity against kinase insert domain receptor (KDR),limiting their feasibility due ......
Four genetic loci affecting swine lung lesions identified by whole-genome sequencing-based associati
[期刊论文] 作者：Zhang,Jiaqi Chen,Zhou Zhang,Jingquan Li,Huipeng Du,Ziqi Ling,Zhongzi Wu,Bin Yang,Shijun Xiao,Huashui Ai,
来源：中国科学：生命科学（英文版） 年份：2021
Dear Editor,rnLung disease is a serious concern in humans and domestic animals.Huge economic losses are caused by enzootic pneumonia in the swine industry worldwide (Maes et al.,2018).The lung can be easily invaded by environmental pathogen......
Raman scattering investigation of twisted WS2/MoS2 heterostructures:interlayer mechanical coupling v
[期刊论文] 作者：Lishu Wu,Chunxiao Cong,Jingzhi Shang,Weihuang Yang,Yu Chen,Jiadong Zhou,Wei Ai,Yanlong Wang,Shun Feng,
来源：纳米研究（英文版） 年份：2021
Twisted van der Waals homo-and hetero-structures have aroused great attentions due to their unique physical properties,providing a new platform to explore the novel two-dimensional (2D) condensed matter physics.The robust dependence of phon......
Mycobacterium Lrp/AsnC family transcriptional factor modulates the arginase pathway as both a sensor
[期刊论文] 作者：Shuangquan Yan,Junfeng Zhen,Yuzhu Li,Yu Huang,Xuefeng Ai,Yue Li,Andrea Stojkoska,Xue Huang,Cao Ruan,Jiang,
来源：遗传学报 年份：2021
L-Arginine is the precursor of nitric oxide (NO),a host immune effector against intracellular pathogens including Mycobacterium tuberculosis (M.tb).Pathogens including M.tb have evolved various strategies targeting arginine to block the pro......
Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed
[期刊论文] 作者：Chao Zhao,Peisi Xie,Ting Yong,Wei Huang,Jianjun Liu,Desheng Wu,Fenfen Ji,Min Li,Doudou Zhang,Ruijin Li,
来源：科学通报（英文版） 年份：2021
Gestational exposure to PM2.5 is associated with adverse postnatal outcomes.PM2.5 can enter alveoli by using intratracheal instillation,even penetrate through l...
[期刊论文] 作者：孟夏,刘聪(校),陈仁杰,郑湃(译),阚海东(校),Francesco Sera,Ana Vicedo-Cabrera,Ai Milojevic Maria,Guo Yuming,Tong Shilu,,
来源：英国医学杂志中文版 年份：2021
目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO2)与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主......
Research Progresses in the Inhibitory Effect of Bone Mesenchymal Stem Cell-Derived Exosome on Blood-
[期刊论文] 作者：Gang Yang,Zhanwei Ruan,Chenbing Wang,Chao Gu,Junjie Lv,Shaojun Yang,Lulu Weng,Feng Ding,Long Ai,Donghai,
来源：生物科学与医学(英文) 年份：2021
Mesenchymal Stem Cells (MSCs) are a type of non-hematopoietic progenitor cells which have self-replication capacity and multilineage differentiation. They have widely applied in studies of various diseases due to their effects in damaged ti......
[期刊论文] 作者：Jia-yuan Zhang,Bo Zhou,Ru-yue Sun,Yuan-li Ai,Kang Cheng,Fu-nan Li,Bao-rui Wang,Fan-jian Liu,Zhi-hong,
来源：细胞研究（英文版） 年份：2021
Pyroptosis is a form of regulated cell death mediated by gasdermin family members,among which the function of GSDMC has not been clearly described.Herein,we demonstrate that the metabolite α-ketoglutarate(α-KG)induces pyroptosis through c......
Handgrip strength and health outcomes:Umbrella review of systematic reviews with meta-analyses of ob
[期刊论文] 作者：Pinar Soysal,Christopher Hurst,Jacopo Demurtas,Joseph Firth,Reuben Howden,Lin Yang,Mark A.Tully,Ai Koyanagi,
来源：运动与健康科学（英文版） 年份：2021
Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-anal-yses of observat...
[期刊论文] 作者：Xiaorui Xing,Weijin Huang,Qi Chen,Na-Na Zhang,Qing Ye,Tian-Shu Cao,Nan Wang,Lei Wang,Lei Cao,Huiyu Wang,Desheng,
来源：国家科学评论（英文版） 年份：2021
Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2.Halting these steps can cure COVID...
Chromosome-scale genomes provide new insights into subspecies divergence and evolutionary characteri
[期刊论文] 作者：Wan,Yan Huang,Hong Li,Mingchun Zhang,Rengui Li,Zhizhong Zhang,Yinghu Lei,Ling Zhang,Heming Zhang,Desheng,
来源：科学通报（英文版） 年份：2021
Extant giant pandas are divided into Sichuan and Qinling subspecies.The giant panda has many species-specific characteristics,including comparatively small organs for body size,small genitalia of male individuals,and low reproduction.Here,w......
Design,synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FG
[期刊论文] 作者：Chunpu Li,Xia Peng,Jihui Zhao,Bao Wang,Yang Dai,Dan Feng,Tianbiao Yang,Hualiang Jiang,Meiyu Geng,Jing Ai,
来源：药学学报（英文版） 年份：2021
Fibroblast growth factor receptors(FGFRs)have emerged as promising targets for anticancer therapy.In this study,we synthesized and evaluated the biological acti...
[期刊论文] 作者：Ce Huang,Enze Zhang,Yong Zhang,Jinglei Zhang,Faxian Xiu,Haiwen Liu,Xiaoyi Xie,Linfeng Ai,Yunkun Yang,,
来源：科学通报（英文版） 年份：2021
The interplay between quenched disorder and critical behavior in quantum phase transitions is concep-tually fascinating and of fundamental importance for understanding phase transitions.However,it is still unclear whether or not the quenche......
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