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[会议论文] 作者：Jia Chen,Dongyang Liu,Qian Zhao,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:Icotinib is a potent small-molecule inhibitor of epidermal growth factor receptor (EGFR)-tyrosine kinase (TKI), which was designed for the treatment of non-small cell lung cancer (NSCLC).It...
A semi-mechanistic population pharmacokinetic model describing the time-dependent kinetics of Red Bl
[会议论文] 作者：Kairui Feng,Xin Zheng,Wenyuan Qi,Pei Hu,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background: XQ (Carfree, Nanjing, China), a new chemical entity that possesses pharmacological activity on PlateletActivating Factor (PAF).XQ was approved into phase Ⅰ evaluation for treatment of isch...
A Mechanistic Pharmacokinetic-Pharmacodynamic Model for the Effect of Esomeprazole in Healthy Subjec
[会议论文] 作者：Dongyang Liu,Hong Yang,Jiaming Qian,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Esomeprazole has proved to be effective for the treatment of gastroesophogeal reflux disease (GERD) and ulcers, where intra-gastric pH value is a biomarker to indicate esomeprazole effects on these di...
Population pharmacokinetic/pharmacodynamic Modeling for Pegylated Recombinant Human Growth Hormone (
[会议论文] 作者：Xin Zheng,Tao Liu,Qian Zhao,Pei Hu,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:CPRC-Y is a pegylatedrecombinant human growth hormone (rhGH) developed with the aim of reducing serum clearance and thereby prolonging the exposure leading to once-weekly sc administration.T...
Predicting whole blood concentrations of zonisamide in human using a physiologically based pharmacok
[会议论文] 作者：Xin Zheng,Kairui Feng,Pei Hu,Jun Shi,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background:Concentration dependent Blood to plasma ratio (B/P) of zonisamide(ZNS) was observed in clinical trial, which requires measuring both plasma concentration and whole blood concentration for c...
[会议论文] 作者：Rui Chen,Dongyang Liu,Jun Shi,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:In vitro information on dextromethorphan (DXM) and the Advanced Dissolution Absorption Metabolism (ADAM) model, incorporated into PBPK simulator Simcyp(@) (v.12) were used to investigate dif...
[会议论文] 作者：Fu Xiaoping,Zhang Xiaohua,Yan Xin,Liu Ji,Jiang Hongxia,
来源：2012全国临床微生物与感染免疫学术研讨会 年份：2012
The main objective of this study was to characterize the molecular characterization of ciprofloxacin-resistant salmonella and the relationship between virulence and resistance of these strains isolate...
[会议论文] 作者：Boyu Ji,Jiang Qin,Alemayehu Nana,Zuoqiang Hao,Toshihisa Tomie,Jingquan LIN,
来源：8th International Conference on Nanophotonics(2015年第八届国际纳米光子 年份：2015
Extinction spectrum,local electric field intensity and temporal response of the local electric field on asymmetric nanocross and a coupled ring dimer-rod na...
Effect of Target-Mediated Drug Disposition on CPRC3 Pharmacokinetics and Pharmacodynamics in Healthy
[会议论文] 作者：Zhenlei Wang,Qian Zhao,Dongyang Liu,Yupeng Ren,Ji Jiang,Pei Hu,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Background: The prevalence of diabetes mellitus (DM) dramatically increased over the past decades.Dipeptidyl peptidase Ⅳ (DPP-4) inhibitors are a relatively new group of anti-diabetic agents.CPRC3 is...
Synthesis and Biological Evaluation of Dasatinib Amino Acid Derivatives as Potential Antitumor Agent
[会议论文] 作者：Fei Liu,LiWei Lang,Ji Jiang,HuaJun Lu,JianMin Wang,Shih-Chen Wang,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Dasatinib was identified as potent orally administered Src/Abl kinase inhibitors with excellent antiproliferative activity against Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia in chro...
[会议论文] 作者：Yingxiang Wang,Don Zhang,Li Zhang,Pei Hu,Dongyang Liu,Ji Jiang,Fenlai Tan,
来源：2009年亚太地区肿瘤生物学和医学学术会议暨第四届中国中青年肿瘤专家论坛 年份：2009
...
Quantitative Estimation of Stratum Corneum Drug Content Obtained Through Tape Stripping and Its Appl
[会议论文] 作者：Wen Zhong,Xia Chen,Qian Zhao,Ji Jiang,Tao Liu,Hong-zhong Liu,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background: Dermatopharmacokinetic (DPK) bioequivalence (BE) evaluation required assessments of stratum corneum (SC) drug content.The SC samples are normall...
[会议论文] 作者：Dongyang Liu,Ji Jiang,Fenlai Tan,Yingxiang Wang,Don Zhang,Li Zhang,Pei Hu,
来源：2009年亚太地区肿瘤生物学和医学学术会议暨第四届中国中青年肿瘤专家论坛 年份：2009
...
Sequential Population Pharmacokinetic and Pharmacodynamic Modeling of Rivaroxaban in Adult and Elder
[会议论文] 作者：Tao Liu,Ji Jiang,Xin Zheng,Qian Zhao,Xia Zhao,Yimin Cui,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Aim:Rivaroxaban (Bayer Healthcare AG, Wuppertal, Germany), an oral, direct factor Xa (FXa) inhibitor for the prevention and treatment of thromboembolic disorders has been approved for nonvalvular atri...
[会议论文] 作者：Wen Zhong,Hong-Zhong Liu,Xin Zheng,Dong-Yang Liu,Jia Chen,Pei Hu,Jun Shi,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background: The distribution of renal function and its effect on drug elimination was not well understood in Chinese population, which impeded the clinical therapeutics for Chinese patients as well as...
Icotinib,a potent and selective oral EGFR inhibitor,is well tolerated and active in patients with NS
[会议论文] 作者：Pei Hu,Jianzhong Shengtu,Dongyang Liu,Fenlai Tan,Yingxiang Wang,Don Zhang,Li Zhang,Qiong Zhao,Ji Jiang,
来源：2009年亚太地区肿瘤生物学和医学学术会议暨第四届中国中青年肿瘤专家论坛 年份：2009
...
Icotinib,a potent and selective oral EGFR inhibitor,is well tolerated and active in patients with NS
[会议论文] 作者：Li Zhang,Pei Hu,Qiong Zhao,Ji Jiang,Long Xu,Jianzhong Shengtu,Dongyang Liu,Fenlai Tan,Yingxiang Wang,,
来源：2009年亚太地区肿瘤生物学和医学学术会议暨第四届中国中青年肿瘤专家论坛 年份：2009
...
Differential regulation of the REGγ-proteasome pathway by p53TGFβ signalling and mutant p53 in cance
[会议论文] 作者：Amjad Ali,Jeffrey N.Myers,Pei Zhang,Jianru Xiao,Bianhong Zhang,Xiaotao Li,Zhuo Wang,Junjiang Fu,Lei Ji,Jiang,
来源：上海市细胞生物学学会第十届CST细胞生物学青年论坛 年份：2014
Proteasome activity is frequently enhanced in cancer to accelerate metastasis and tumorigenesis REGγ, a proteasome activator known to promote p53/p21/pl 6 degr...
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