Dnmt3B相关论文
目的 探究DNMT3b在膀胱癌组织中的表达及与经尿道膀胱肿瘤电切术后复发的相关性。方法 选取膀胱癌患者82例，并收集患者临床资料。免......
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目的:基于生物信息学分析和临床数据分析,探究DNA甲基化转移酶（DNMTs）基因在急性髓系白血病（AML）中的表达和突变及其与AML生存、预后和......
目的 探讨大黄对ICH模型大鼠的血脑屏障保护作用机制.方法 将50只Wistar雄性大鼠随机分成5组:空白组、假手术组、ICH组、安宫牛黄......
目的 研究结直肠癌、癌前病变及癌旁、癌前病变旁组织中SETP9 甲基化水平与DNMT3b 表达的相关性，探讨DNMT3b 表达对SEPT9 甲基化的......
Zinc Fingers and Homeoboxes 2 (ZHX2) Regulates the Expression of DNA Methyltransferase 3B (DNMT3B) i
Background: Aberrant DNA methylation were associated with many kinds of human tumors, including hepatocellular carcinoma......
Demethylation of Cxcr3 gene promoter and upregulation of CXCL10 after spinal nerve ligation contribu
DNA methylation has been implicated in the pathogenesis of chronic pain.Here we investigated how chemokine receptor CXCR......
目的：检测甲基苯丙胺(methamphetamine,METH)诱导行为敏化小鼠的伏隔核中miR-29家族(miR-29b/c)及其靶基因Dnmt3b的表达变化.方法：将......
OBJECTIVE To evaluate the association between DNMT3A,DNMT3B and SETD2 genetic variations and the chemosensitivity and di......
Downregulation of Maternally Expressed Gene 3 by Nickel Contributes to Malignant Transformation of H
BACKGROUND:Maternally expressed gene 3(MEG3),a long noncoding RNA,downregulation has been reported in some cancer tissue......
Overexpression of Maelstrom Promotes Bladder Urothelial Carcinoma Cell Aggressiveness by Epigenetica
Background: We have recently identified and characterized a novel oncogene,maelstrom(MAEL)from 1q24,in the pathogenesis ......
Distinct roles of DNMT1-dependent and-independent methylation patterns in the genome of mouse ES cel
Background: DNA methylation patterns are critical for genome stability and gene transcription, and are initiated by de n......
构建敲除DNMT3B基因的细胞系,为重组蛋白药物生产使用的高效表达系统提供DNMT3B基因缺失的稳定细胞株.采用CRISPR/Cas9基因编辑技......
ERα increases global DNA methylation and suppresses the drug response of breast cancer cells through
Aberrant DNA methylation is the first epigenetic marker associated with chemotherapy resistance.However,the acquisit......
MicroRNAs 玩在各种各样的癌症的发展和前进的重要角色，包括舌头有鳞的房间癌(TSCC ) 。miR-29b 和 miR-195 被报导了是在 TSCC 的......
目的:检测DNA甲基化转移酶(DNA methytransferase,DNMT)DNMT3B基因启动子区-149位点C46359T单核苷酸多态性(Single Nucleotide Pol......
AIM: To investigate the relationship between 579 G＞T polymorphisms in the DNMT3B gene, which is involved in de novo methy......
Effects on Biological Behavior of Bladder Carcinoma T24 Cells via Silencing DNMT1 and/or DNMT3b with
In this study,RNA interference technique was employed to silence the expression of DNMT1 and/or DNMT3b in human bladder ......
目的:从分子信号通路水平更多地揭示体外受精(IVF)致胎盘生长动力轨迹改变的机制,为促进和改善IVF的体外操作提供理论支持和预警靶......
目的 探讨免疫缺陷-染色体着丝粒不稳定-面部畸形(ICF)综合征的临床特征、免疫表型、基因诊断及治疗,提高对该病的认识.方法 回顾......
目的探讨被转化生长因子b激活的长链非编码RNA(Long non-coding RNA activated by transforming growth factor-b,lnc RNA-ATB)对......
背景:膀胱癌在泌尿系统的恶性肿瘤疾病发病率中高居第二,每年在全世界范围内有两百万人罹患此病,近年来随着治疗技术的进步死亡率......
目的:上皮性卵巢癌早期多无明显症状,且无特异性的筛查手段,约70%患者在确诊时已发展至晚期。晚期患者的主要治疗方式为肿瘤细胞减......
背景:肾癌是常见的泌尿系统恶性肿瘤,中位无进展生存期较低。舒尼替尼是治疗晚期肾癌最有效的药物之一,虽然舒尼替尼治疗肾癌已经......
癌症是未来人类必须要攻克的医学难关。中国由于经济发展起步比较迟,大部分人的生活水平提升较慢,加之生活和工作压力较大,所以人......
为揭示DNA甲基转移酶3B(DNMT3B)在肝癌中是否参与了肿瘤的发生,应用Westernblotting及细胞免疫化学方法分析DNMT3B蛋白在人的正常......
为研究lncRNA对鸡骨骼肌生长的影响,在UCSC上预测lncRNA-FKBP1C顺式调控的靶基因为DNMT3B,随后采用qPCR检测DNMT3B在隐性白羽洛克......
目的:探讨沉默DNMT1和DNMT3b基因对胰腺癌BxPC-3细胞p16,RASSF1A基因启动子甲基化的影响。方法:将胰腺癌BxPC-3细胞分为5组:DNMT1......
,Progressive silencing of the zinc transporter Zip8 (Slc39a8) in chronic cadmium-exposed lung epithe
Cadmium (Cd),a non-essential metal,stealthily enters the cells by utilizing the essential metal importing pathways.The z......
目的:研究妊娠过程小鼠子宫内膜DNA甲基转移酶( DNA methyltransferases,DNMTs)DNMT1,DNMT3a和DNMT3b的表达规律以及它们对胚胎着......
目的 探讨DNA甲基化转移酶3b(DNMT3b)对人肝癌细胞株SMMC-7721中DLC-1基因的表达及其启动子区甲基化状况的影响.方法 将SMMC-7721......
Critical role of △DNMT3B4/2 in regulating RASSF1A promoter specific DNA methylation in non-small cel
Background △DNMT3B (a new DNMT3B subfamily) expression is initiated through a novel promoter.We identified at least 7 t......
目的 探讨稳定低表达DNA甲基转移酶3b(DNMT3b)基因对人膀胱癌细胞生长和凋亡的影响.方法 包装表达DNMT3b siRNA和阴性对照siRNA的......
目的 研究5-氮杂-2-脱氧胞苷(5-aza-CdR)在肝癌细胞株SMMC7721中对程序性细胞死亡因子4(PDCD4)表达的影响及可能机制.方法 培养肝......
Effects on Biological Behavior of Bladder Carcinoma T24 Cells via Silencing DNMT1 and/or DNMT3b with
In this study,RNA interference technique was employed to silence the expression of DNMT1 and/or DNMT3b in human bladder ......
Critical role of △DNMT3B4/2 in regulating RASSF1A promoter specific DNA methylation in non-small cel
Background △DNMT3B (a new DNMT3B subfamily) expression is initiated through a novel promoter.We identified at least 7 t......
目的探讨双酚A对MCF-7细胞内整体DNA甲基化水平及甲基化转移酶的影响。方法分别将浓度为10-6mol/L、10-7mol/L的双酚A作用于MCF-7......
目的分析胎儿宫内暴露重金属与脐带血中DNA甲基转移酶3B(DNMT3B)基因甲基化的关系。方法本研究基于在山西开展的病例对照研究,共纳......
目的探讨被转化生长因子b激活的长链非编码RNA(lncRNA-ATB)对瘢痕疙瘩成纤维细胞增殖和凋亡的影响,并分析其作用机制。方法检测瘢......
目的探讨散发性乳腺癌中DNA甲基转移酶（DNMT）3a、DNMT3b蛋白表达情况及其与雌激素受体（ER）α基因启动子甲基化状态及蛋白表达的关系。......
目的探讨散发性乳腺癌中DNA甲基转移酶（DNMT）3a、DNMT3b蛋白表达情况及其与雌激素受体（ER）α基因启动子甲基化状态及蛋白表达的关系。......
AIM:To investigate the relationship between 579 G>T polymorphisms in the DNMT3B gene, which is involved in de novo methy......
目的分析江苏宿迁地区汉族人群DNA甲基转移酶3B（DNMT3B）基因启动子区-149C〉T和-579G〉T单核苷酸多态性（SNP）与食管癌（EC）易感性的关系。......
肾细胞癌是我国泌尿系统常见的肿瘤之一。肿瘤的发生与抑癌基因的失活有关，研究发现，抑癌基因甲基化是其失活的重要机制之一。甲基化......
目的 探讨雌激素对子宫内膜上皮细胞雌激素受体α（ERα）mRNA表达的影响及其可能的作用机制。方法 采用RT-PER方法检测分别经雌激素和......
