Ketolide antibiotics have been in clinical practice has been widely used,owing to its broad antimicrobial spectrum,conve......

根据酮内酯的构效关系和生物电子等排原理，设计、合成了新型C12吡唑啉酮酮内酯（1）．1以吡唑啉酮结构单元替代泰利霉素11，12-氨基甲酸内酯......

3-酮基-红霉素化合物是合成酮内酯化合物的关键中间体,由相应的3-羟基红霉素化合物氧化得到.本文对3-羟基-6-O-甲基红霉素（Ⅱ）生成3-......

Antibiotic macrolides are experiencing renewed interest in anti-infective therapy since the advent of ketolides. This th......