PHARMACOGENETICS相关论文
Pharmacogenetics of medication-related osteonecrosis ofthe jaw:a systematic review and meta-analysis
Objective Bisphosphonates are commonly administered as bone-specific anti-resorptive agents to patients who at increased......
FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISMS AND DISTINCT HAPLOTYPES OF MDR1 GENE IN CHINESE HAN POP
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Histamine interacts with histamine H4 receptor (HRH4) to impact antipsychotic response.Pharmacogenetic information about......
Objective To investigate whether genetic polymophisms in SLC17A7 gene is associated with serotonin reuptake inhibitors (......
An investigation of genetic, cognitive and neuroendocrine markers for predicting antidepressant resp
Objective:To test the hypothesis that a tentative integrative model by combining genetics, neuroendocrine and cognition ......
Backgrounds The participating of clinical pharmacists has been demonstrated as a successful mode in western countries bu......
OBJECTIVE The nucleus accumbens(NAc),a part of basal ganglia(BG),has been reported to play a role in motivation and rewa......
Association analysis of 5-HT2A receptor polymorphisms with risperidone treatment efficacy in Chinese
The 5-HT2A receptor is one of the most important serotonin receptors, serving as major targets for risperidone, an atypi......
Association Analysis of HTR2A Polymorphisms with Risperidone Treatment Efficacy in Chinese Han Schiz
The 5-HT2A receptor is one of the most important serotonin receptors, serving as major targets for risperidone, an atypi......
目的 探讨维生素K环氧化物还原酶复合体亚单位1基因(vitamin K epoxide reductase complex subunit 1,VKORC1)、细胞色素P450 2C9......
哮喘治疗药物生物通路的基因多态性研究是指运用遗传药理学的方法，如全基因组关联研究（GWAS）、候选基因研究（CGS）、基因组测序、混合作......
AIM: To analyse the role of two common polymorphisms in genes coding for histamine metabolising enzymes as it relates to......
目的 研究有机阴离子转运蛋白1B1(SLCO1B1)基因D130N多态性与瑞格列奈治疗新诊断2型糖尿病疗效之间的相关性.方法 选取新诊断的2型......
目的 观察ABCG8 T400K基因多态性与阿托伐他汀降脂疗效的关系.方法 选取186例高脂血症病人(男、女各93例),口服阿托伐他汀(20 mg,q......
目的综合评价CYP2C9和VKORC1基因检测指导华法林给药的有效性和安全性。方法采用Meta分析方法,制定原始文献的纳入标准、排除标准......
Pharmacogenomics is the study of the impact of genetic variations or genotypes of individuals on their drug response or ......
Aim: The aim of the present study was to investigate the relationship between R219K, M883I, and R1587K variants of the A......
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Current pharmacogenetic studies have obtained many genetic models that can predict the therapeutic efficacy of anticance......
目的 探讨高血压药物基因组学在治疗民航飞行员原发性高血压中应用的意义及前景. 方法 对民航某航空公司17例原发性高血压飞行员的......
Background Patients with the genotypes of both CYP2C9*3/*3 and VKORC1-1639 A/A are expected to require the lowest dose o......
In clinical practice, patients undergoing chemotherapy display prominent individual differences, adverse reactions and s......
Pharmacogenetics and pharmacogenomics deal with the role of genetic factors in drug effectiveness and adverse drug react......
The clinical course of Crohn’s disease and ulcerative colitis is highly variable between patients,and this has therapeu......
In the treatment of tumor patients, how to select the chemotherapy regimen with better efifcacy, less toxicity and expen......
Background Patients with the genotypes of both CYP2C9*3/*3 and VKORC1-1639 A/A are expected to require the lowest dose o......
目的：探讨ERCC1 Asn118Asn和XRCC1 Arg399Gln多态性与中国汉族晚期大肠癌患者对奥沙利铂（Oxaliplatin，L-OHP）一线化疗临床效果的关系。......
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are d......
胆固醇水平升高是动脉粥样硬化发病的主要原因。瑞苏伐他汀为临床常用的抑制胆固醇合成的药物,其药动学和药效学存在显著个体差异......
遗传药理学认为种族和个体遗传差异是导致药物不良反应和个体用药差异的主要因素。依据基因型个体化给药是避免药物不良反应，产生有......
伴随着遗传药理学的发展，人们逐渐认识到基因多态性不能完全解释降压药物疗效的个体差异。在分子水平上，高血压药物相关代谢酶、受体......
【正】BACKGROUND: The immunosuppressive drugs used worldwide have a narrow therapeutic index, which results in a need to......
化学治疗是乳腺癌主要的治疗方法之一,个体在化疗疗效及毒性反应方面存在很大的个体差异,药物代谢酶基因的改变可以在一定程度上解......
在人，睾丸激素(T) 缺乏也就是与减少的物理性能被联系，在身体作文由不利特点定义增加的身体脂肪内容和减少的肌肉集中。在雄激素缺乏......
瞄准：为了在作为它为组织安 metabolising 酶编码的基因分析二普通多型性的角色，联系到风险开发 ulcerative (UC ) 和这些病人的临床......
Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patie
The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant.However,despite......
During the past two decades the first sequencing of the human genome was performed showing its high degree of inter-indi......
During the past two decades the first sequencing of the human genome was performed showing its high degree of inter-indi......
Predicting (side) effects for patients with inflammatory bowel disease: The promise of pharmacogenet
Inflammatory bowel disease (IBD) is a chronic and heterogeneous intestinal inflammatory disorder. The medical management......
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Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in
调查在溶质搬运人家庭 30 之间的一种潜在的关系(锌 transporter ) 的目的成员 8 (SLC30A8 ) 在对待最新诊断的汉语的 rosiglitazo......
银屑病是常见的慢性复发性皮肤病之一，其治疗药物种类繁多，对不同患者疗效及药物毒副作用各异。与银屑病治疗相关的药物基因组学研究......
奥沙利铂（L-OHP）是消化道肿瘤化疗中应用最广的药物之一,以其为基础组成的FOLFOX4方案已成为进展期结、直肠癌公认的标准化疗方案。......
目的 建立对七氟醚敏感性不同的果蝇品系。方法 将６～８日龄华阴Ｍ３野生型雌、雄果蝇放入特制的玻璃麻醉室内，逐渐加大七氟醚浓度实施麻醉......
药物遗传学为研究影响药物治疗结果的遗传学(基因)因素的学科.该文主要对药物遗传学与肿瘤药物治疗(包括药物治疗结果与毒副反应)......
CYP2C19＊2, CYP2C19＊3, CYP2C19＊17 Allele and Genotype Frequencies in Clopidogrel-Treated Patients wit
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Irinotecan is now regarded as the most active drug for the treatment of colorectal cancer.However,one of the most diffic......
