Phosphodiesterase相关论文
Efficacy and safety of oral SK3530 for the treatment of erectile dysfunction in Korean men: a multic
Aim: To evaluate the efficacy and safety of SK3530, a newly developed type 5 phosphodiesterase inhibitor (PDE5I), in Kor......
Objective Biophoton is an extremely weak photon beam radiated spontaneously by the organisms under the physiological or ......
Neuroprotective Effects of Papaverine on Retinal Ganglion Cells in a Rat Optic Nerve Transection Mod
Objective Elevation of intraocular cAMP facilitates neuronal survival in CNS.Papaverine is an panphosphodiesterase inhib......
Objective Phosphodiseterase (PDE) is a superfamily of enzymes that catalyzes the hydrolysis of intracellular cAMP and/or......
Comparison of phosphodiesterase 7 expres⁃sion in brain striatum of C57BL/6J and DBA/2J mice and asso
OBJECTIVE Cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling has been shown to regulate alcohol consump......
视网膜变性动物模型是研究人类遗传性视网膜变性疾病治疗的重要工具,目前常用于基础研究的视网膜变性动物模型包括系列视杆细胞变......
环二鸟苷酸(c-di-GMP)是细菌中一种重要的第二信使,能够调控多种生理活动.C-di-GMP由两个GTP分子经环化酶(DGCs)合成,而被磷酸二酯......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的 观察急性脑梗死患者血小板磷酸二酯酶(PDE)亚型活性变化,探讨影响其因素.方法 对30例急性脑梗死患者分别于发病第1、4、8、15......
主要研究了麦牙根中5'－磷酸二酯酶的提取方法。采用细度40目的原料，通过正交试验确定最佳提取工艺为：加水6倍，pH5．0，在4℃条件下浸提......
西地那非被广泛应用于治疗阴茎勃起功能障碍(ED),由于许多ED患者同时患有心血管疾病,这类疾病患者应用西地那非治疗的安全性一直是......
目的:观察人参皂甙Rg1对磷酸二酯酶5(PDE5)酶活性的影响.方法:应用125I放射免疫法,测定不同浓度的人参皂甙Rg1对PDE5活性的影响,并......
目的 研究法乐四联症(TOF)患者术后早期血流动力学变化规律，探讨术后低心排趋势的监测方法与防治措施。方法 TOF患者20例，平均年龄(3......
本文采用磷酸二酯酶法测定了银屑病患者表皮和血清中钙调素(Calmodulin,CaM)含量,并报道了血清中无机磷的升高。健康人表皮CaM含量......
<正> 钙调素(Calmodulin,CaM)是一类分子量16 700左右的钙结合蛋白,在真核细胞中激活多种具重要功能的酶类。目前已知某些CaM拮抗......
【目的】以茶碱为参照,观察中药成分牛蒡子苷对原代骨骼肌细胞磷酸二酯酶（Phosphodiesterase,PDE）活性及蛋白质合成的影响,探讨中药......
【目的】以猪中性粒细胞为靶细胞,研究白芍制剂对其相关功能（呼吸爆发和弹性蛋白酶释放）及磷酸二酯酶活性的影响。【方法】中性粒细......
目的：研究羟苯氨酮（ｏｘｙｐｈｅｎａｍｏｎｅ，Ｏｘｙ）强心作用的生化机理。方法：采用Ｎａ＾＋，Ｋ＾＋－ＡＴＰ酶活性和ｃＡＭＰ－ＰＤＥ活性、肌浆网Ｃａ＾２＋－ＡＴＰ酶活性和ｃＡＭＰ含量以及心肌肌原纤维Ｃａ２＾＋，Ｍｇ＾２－ＡＴＰ酶活性等测定法，研究Ｏｘｙ对它们的影......
Improved spontaneous erectile function in men with mild-tomoderate arteriogenic erectile dysfunction
瞄准：为了测试假设，那 sildenafil (为一年夜里的 50 mg ) 能与 mild-to-moderate arteriogenic 在人改进自发的可勃起的功能(EF ) ......
Efficacy and safety of oral SK3530 for the treatment of erectile dysfunction in Korean men： a multic
瞄准：评估 SK3530 的功效和安全，一种最新发达的类型 5 phosphodiesterase 禁止者(PDE51 ) ，在有可勃起的机能障碍(编辑) 的朝鲜的人......
目的建立血清磷酸二酯酶（PDE）活性测定的HPLC方法并探讨其在脑梗死患者的临床意义。方法分离293例脑梗死患者和148例对照组外周血白......
为探明磷酸二酯酶（phosphodiesterase，PDE）在犬中枢神经活动中的作用，采用反转录聚合酶链反应检测18个PDE亚型在犬中枢神经不同部位中（......
目的:提取动物体的cAMP磷酸二酯酶(PDE),并检测其活性,为兽医临床研究PDE活性的生理病理变化和中西药物对PDE活性调节作用建立实验......
目的:探讨伊菠丁基甲基黄嘌呤对海马区环磷酸鸟苷(cGMP)合成的影响. 方法: 嵌夹沙土鼠的双侧颈总动脉复制的脑缺血模型,应用免疫荧......
本实验采取放射配基结合法、放射酶测定法和放射免疫法观察了过敏性哮喘豚鼠肺组织β受体、cAMP-PDE活力和cAMP的变化。哮喘组与对......
磷酸二酯酶(PDEs)基因家族已扩大到11个.新的PDE酶包括PDE7B,PDE8,PDE9A,PDE10A,PDE11A.新发现的PDEs在调节阴茎勃起功能、胰岛素......
Ｅｆｆｅｃｔｓｏｆｉｎｓｕｌｉｎ ｍｅｄｉａｔｏｒｏｎｐｈｏｓｐｈｏｄｉｅｓｔｅｒａｓｅａｃｔｉｖｉｔｙａｆｔｅｒｓｃａｌｄｉｎｇｉｎｒａｔｓＸｕＬｉｎｓｈｕｉ（许霖水），ＷｕＸｉｇｕｉ（吴喜贵）（ＤｅｐａｒｔｍｅｎｔｏｆＢｉｏｃｈｅｍｉｓｔｒｙ，Ｔ.........
研究了轻稀土离子（Ｌｎ＾３＋）对钙调蛋白（ＣａＭ）调控的磷酸二酯酶（ＰＤＥ）活力的影响，结果表明，在无Ｃａ＾２＋的ＣａＭ（Ａｐｏ－ＣａＭ）体系中，由ＣａＭ调节的ＰＤＥ的活力随Ｌｎ＾３＋浓度的变化曲线呈双相效应，即在高浓......
目的建立大鼠脑组织磷酸二酯酶(PDE)活性测定的HPLC法.方法大鼠脑组织匀浆后,可溶部分为酶样品,以cAMP和cGMP为反应底物,采用双管......
目的 探讨磷酸二酯酶(PDE)4D基因多态性与缺血性脑卒中的关系.方法 选取121例缺血性脑卒中患者(病例组)和130例健康对照者(对照组)......
目的:探讨尿5'-核苷酸磷酸二酯酶(5'-NPD)能否反映顺铂导致的早期肾损害.方法:采用完全随机设计方法,建立顺铂致大鼠肾损......
Phosphodiesterase inhibitors for treatment of voiding dysfunction:An overview of experimental and cl
Recently,the focus of the origin of lower urinary tract symptoms(LUTS)has change from the prostate to the bladder.Regard......
Urine chemokine levels correlate with treatment response to phosphodiesterase 4 inhibitor in prostat
AIM To investigate the association of urinary chemokines with the treatment response in chronic prostatitis/chronic pelv......
选用磷酸二酯酶3(PDE3)特异性抑制剂Milrinone和PDE4特异性抑制剂Rolipram以及细胞周期蛋白依赖性激酶(cdk)抑制剂Roscovitine(ROS......
Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP^+ -induced decline of
OBJECTIVE Parkinson disease (PD) is a chronic neurodegenerative disorder caused by progressive dopaminergic neuronal dea......
Depression is a recurring and potentially lifethreatening disorderthat is major cause of morbidity and mor-tality. Stres......
Forskolin Modulates the Inhibitory Effect of C-Type Natriuretic Peptide on Hypoxia-Induced Atrial Dy
Our study investigated effects of C-type natriuretic peptide (CNP) on atrial dynamics and hypoxia inducible factor 1 alp......
Erectile Dysfunction among Diabetic Men in Two Medical Centers in Burkina Faso: Epidemiological, Dia
Objective: To study erectile dysfunction in diabetic patients seen in two clinics in the city of Bobo-Dioulasso, Burkina......
洛土辛（Ｌｏｔ）系莲子心中的一种新型生物碱单体。Ｌｏｔ、氨力农（Ａｍ）和罂碱（Ｐａ）剂量依赖性地增加离体心肌的收缩力且Ｌｏｔ的作用强于Ａｍ和Ｐａ。Ｌｏｔ３０μｍｏ１／分别使豚鼠、大鼠、......
FCPR16 induces AMPK-dependent autophagy and provides neuroprotection in SH-SY5Y cells and neurons ex
OBJECTIVE The cause of Parkinson disease (PD) is generally not clear, but it is considered to be related to excessive ox......
Icariside Ⅱ, a PDE5 inhibitor, attenuates cerebral ischemia/reperfusion injury through activating BD
OBJECTIVE To explore the effects and mechanism of icariside Ⅱ(ICS Ⅱ),a pharmacologically active compound derived from ......
Heart failure (HF) is the leading cause of morbidity and mortality and is evolving to epidemic proportions. Despite phar......
Background: Phosphodiesterase inhibitors (PDI) are used in cardiac surgery to improve and stabilize cardiac function aft......
Background:Phosphodiesterase 4(PDE4)is a promising target for the treatment of Parkinson’s disease(PD).However,the unde......
Two selective phosphodiesterase-4 (PDE4) inhibitors—viz., crisaborole (Eucrisa®, Pfizer) and apremilast (Otezla®......
Introduction: There is substantial evidence suggesting the additive effect on erectile function (ED) of testosterone and......
The importance of nitric oxide(NO) in vascular physiology is irrefutable;it stimulates the intracellular production of c......
Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabe
AIM To determine how statins, testosterone(T) replacement therapy(TRT) and phosphodiesterase 5-inhibitors(PDE5I) influen......
Effects of TNFAIP3 and PDE4B on apoptosis and invasion of tumor cells in diffuse large B cell lympho
Objective: To study the effects of TNFAIP3 and PDE4B on apoptosis and invasion of tumor cells in diffuse large B cell ly......
Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreat
Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death......
