SINOMENINE相关论文
Sinomenine (SIN) is a bioactive alkaloid compound extracted from a Chinese medicinal plant Sinomenium acutum.It is a mul......
Sinomenine attenuates lipopolysaccharide-induced osteolysis via the inhibition of NF-κB signaling pa
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Sinomenine inhibits TNF-α induced proliferation and α7nAChR expression in fibroblast-like synoviocyt
Aim:To investigate the potential association of the fibroblast-like synoviocytes (FLS) aggressive proliferation with α7......
Sinomenine decreases MyD88 expression and improves inflammation-induced joint damage progression and
objective Sinomenine (SIN) is the active principle of the Chinese medical plant sinomenium acutum which is widely used f......
Anti-inflammation Effects of Sinomenine on Macrophages through Suppressing Activated TLR4/NF-κB Sign
Sinomenine(SN)has been used in the clinical treatment of systemic lupus erythematosus and rheumatoid arthritis for many ......
Influence of sinomenine on protein profiles of peripheral blood mononuclear cells from ankylosing sp
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Enrichment and separation of sinomenine and acutumine from the crude extract of Sinomenium acutum by
pH-Zone-refining counter-current chromatography was successfully applied to the enrichment and separation of alkaloi......
Cumulated date suggest that the failure of lung cancer treatment aremainly due to tumor invasion and metastasis.STAT......
Objective:To investigate the protective effect of sinomenine stellate ganglion block(SGB)on chronic myocardial ischemia ......
目的 探讨吗啡依赖大鼠催促戒断模型与条件性位置偏爱模型大鼠脑内单胺类递质的变化以及中药活性成分青藤碱对其的影响.方法 采用......
目的研究青藤碱联合甲氨蝶呤对佐剂性关节炎(adjuvant arthritis，AA)大鼠的治疗机制和作用。方法弗氏完全佐剂诱导大鼠AA，随机分为模......
目的:探讨青藤碱(SIN)对小鼠皮肤移植排斥反应的免疫抑制作用。方法:BALB/c小鼠作为供体,C57BL/6小鼠作为受体,建立背-背皮肤移植......
Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics i
AIM: To investigate the effect of release behavior of sustained-release dosage forms of sinomenine hydrochloride dosage ......
目的 研究青藤碱(SIN)对肿瘤坏死因子α(TNF-α)刺激引起的人脐静脉内皮细胞(HUVEC)核因子(NF)κB p65的核移位的影响.方法 从新鲜......
目的:观察青藤碱(SN)对脂多糖(LPS)诱导的类风湿关节炎(RA)患者外周血单核细胞TLR4/MyD88/NF-κB mRNA及蛋白表达的影响.方法:采用......
制备局部给药的青藤碱喷雾剂,评价该制剂的特征.以体外经皮渗透试验筛选渗透促进剂;以稳定性试验考察抗氧剂的作用;以药代动力学试......
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Aim: The aim of this study was to investigate the mechanism of the effects of Sinomenine (SIN) on the invasion and migra......
Objective: Premature and ill neonates undergo painful but medically necessary procedures while hospitalized.Although opi......
Effects and safety of Sinomenine in treatment of rheumatoid arthritis contrast to methotrexate: a sy
OBJECTIVE: To systematically evaluate the curative clinical efficacy and safety of sinomenine(SIN) in treatment of rheum......
为了探讨青藤碱（SM）对体外人肝星状细胞（LX-2）增殖和凋亡的影响。使用不同浓度（0.4、0.8、1.6、3.2、6.4 mmol/L）SM溶液体外作用LX-2细胞......
Therapeutic effect of an injectable sustained-release sinomenine hydrochloride and sodium hyaluronat
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Influence of sinomenine on protein profiles of peripheral blood mononuclear cells from ankylosing sp
Background Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease which lacks satisfactory treatment so ......
目的 探讨青藤碱(sinomenine,SN)对胶原诱导性关节炎(collagen-induced arthritis,CIA)小Toll样受体4(toll like receptor 4,TLR4)......
目的研究青藤碱的免疫抑制作用是否与核因子-κB的活性有关.方法以实验性自身免疫性脑脊髓炎大鼠为免疫异常模型,观察青藤碱对其临......
目的：观察青藤碱联合医用臭氧局部注射治疗腰背肌筋膜炎的临床疗效。方法腰背肌筋膜炎患者60例，随机分为两组，每组30例。观察组采用青......
目的 探讨青藤碱对大鼠心脏移植慢性排斥反应抑制作用的可能机制.方法 PVG大鼠作为供体、DA大鼠作为受体,所有大鼠在移植后的10 d......
目的 研究青藤碱对小鼠肾脏缺血再灌注(IR)损伤的作用及其机制.方法 C57BL/6小鼠静脉注射青藤碱200 mg/kg,对照组注射等体积生理盐......
The title compound (9S,13R,14S)-7,8-dehydro-4-(4-bromo-benzyloxy)-3,7-dime- thoxy-17-methyl-morphinan-6-one monohydrate ......
Synthesis and Crystal Structure of (7R,8S,9S,12S)-13,14-dehydro-1-(4-fluorobenzy oxy)-N-methyl-2,13-
The title compound (7R,8S,9S,12S)-13,14-dehydro-1-(4-fluorobenzyloxy)-N-methyl-2,13-dimethoxy-12-hydroxymorphinane was s......
Therapeutic effect of an injectable sustained-release sinomenine hydrochloride and sodium hyaluronat
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Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis (RA).In a continuous research aiming......
目的探讨青藤碱对脂多糖诱导损伤的H9c2大鼠心肌细胞的保护作用及其机制。方法将H9c2大鼠心肌细胞分为正常对照组、脂多糖组和青藤......
目的体外培养脂多糖(LPS)诱导的初生小牛关节软骨细胞炎症损伤模型并以青藤碱(SN)干预，从而研究SN对关节软骨细胞的保护作用。方法......
采用软件AutoDock Vina将青藤碱及其衍生物青藤碱4-羟基亚麻酸酯(SLN)与28个和缺血性脑卒中有关的靶点蛋白进行分子对接,预测青藤......
目的探讨青藤碱免疫抑制作用,为其在器官移植免疫抑制治疗上的应用提供实验依据.方法建立48个大鼠原位肾移植急性排斥反应模型(Wis......
以改进型Ｆｒａｎｚ扩散池为经皮吸收研究装置，ｐＨ６．８磷酸缓冲液为接收液，裸鼠皮肤为实验皮肤，ＨＰＬＣ法测定青藤碱含量，采用均匀设计法从氮酮，丙二醇，油酸中选择......
目的：研究凝胶中青藤碱游离碱的体外经皮渗透特性。方法：采用改良的Franz扩散池法考察经皮渗透性能，以离体大鼠皮肤为经皮渗透屏障，通......
目的:研究青藤碱(sinomenine,SIN)对肾移植大鼠存活时间及IL-2的影响,探讨SIN免疫抑制作用的可能机制.方法:实验分四个组,采用改良......
目的:探讨青藤碱对脂多糖诱导的RAW264.7巨噬细胞炎症的影响和机制。方法:以小鼠RAW264.7巨噬细胞为研究对象,在有或无血红素氧合......
采用电位滴定法测定了盐酸青藤碱的电离常数，其数值在ｔ＝（２５±０．５）℃时，ｐＫａ＾Ｔ＝７．９７±０．０２。......
目的研究青藤碱对小鼠骨髓树突状细胞(dendritic cell DC)免疫功能的影响.方法小鼠骨髓细胞用GM-CSF培养7 d,再加入不同浓度青藤碱......
仿透皮吸收实验方法对青藤碱贴片的溶出度进行了考察，结果表明青藤碱体外释药随时间为一递增过程，符合Ｈｉｇｕｃｈｉ方程。......
本实验研究了青藤碱对实验性心律失常的作用。实验结果表明,青藤碱可缩短印防己毒素诱发家兔心律失常的持续时间;具有对抗BaCl_2诱......
目的:本文建立了用高效液相色谱法同时测定双活祛风镇痛酒(青风藤、丹参等)中青藤碱和丹参酮ⅡA的含量的方法.方法:固定相为Water......
目的：探究青藤碱（SIN）诱导肺癌NCI-H460细胞凋亡的作用机制。方法：四甲基偶氮唑蓝（MTT）法测定SIN对肺癌NCI-H460细胞生长的影响;Western ......
目的观察青藤碱对高侵袭性人结肠癌细胞株SW 480移植瘤细胞周期及结肠瘤体组织中环氧合酶-2（COX-2）表达的影响,研究青藤碱防治结肠癌......
目的:研究青藤碱(sinomenine,SIN)对吗啡依赖小鼠、大鼠及豚鼠离体回肠催促戒断反应的抑制作用.方法:连续递增sc吗啡(morphine,Mor......
