Silencing相关论文
Gene Overexpression and Gene Silencing in Birch using an Agrobacterium-Mediated Transient Expression
As transient expression systems are effective methods for the functional characterization of genes, a transient gene exp......
A microRNA-21-responsive doxorubicin-releasing sticky-flare for synergistic anticancer with silencin
A sticky-flare gold nanoparticle probe(AuNP-probe)is designed by the combination of locked nucleic acid functionalized s......
Transient silencing mediated by in vitro synthesized double-stranded RNA indicates that PsCdc14 is r
In many eukaryotic organisms,Cdc14 phosphatase regulates multiple biological events during anaphase and is essential for......
RNA silencing is a conserved mechanism found ubiquitously in eukaryotic organisms.It has been used to regulate gene expr......
In this paper,a series of peptide-siRNA conjugates with phosphodiester unit as the linker targeting to Cdc2 gene were sy......
A disulfde-modifed nucleoside was designed and synthesized. After loading the modifed nucleoside on controlled pore glas......
microRNAs(miRNAs)是一类长约23个核苷酸的非编码小RNA,通过其诱导的沉默复合物(miRNA-induced silencing complex,miRISC)在转录......
Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fib
OBJECTIVE Epithelial-mesenchymal transition(EMT)is a phenotype conversion that plays a critical role in the development ......
RNA interference(RNAi)is an adaptive defense mechanism through which double-stranded RNAs silence cognate genes in a se......
Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus
While human immunodeficiency virus 1(HIV-1) infectionis controlled through continuous, life-long use of a combination of......
Silencing-specific methylation and single nucleotide polymorphism of hMLH1 promoter in gastric carci
AIM:To investigate CpG methylation and single nucleotidepolymorphism(SNP)of a specific promoter region of hMLH1in prima......
Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastri
AIM:To investigate the rrelationship between methylationof Syk(spleen tyrosine kinase)gene in promoter regionand oncoge......
To understand the DNA-methylation mediated gene silencing mechanisms, we analyzed in cell culture of the promoter functi......
Plants and viruses coexist in the natural ecosystem for extended periods of time,interacting with each other and even co......
AT1a Receptor Has Interacted with Angiotensin-converting Enzymes 2 mRNA Expression in Mouse Brainste
Objectives To examine in vivo interactions between angiotensin Ⅱ (Ang Ⅱ) AT1a receptor (AT1aR), angiotensin-converting......
2009215 Construction of the specific MUC5AC-siRNA expression plasmid and effect of siRNA on proliferation and apoptosis ......
Use of RNAi silencing to target preconditioned glial cell line-derived neurotrophic factor in neuron
Several studies have suggested that exogenous glial cell line-derived neurotrophic factor may pro-tect neurons from cere......
The binding of nuclear proteins prepared from mouse erythroid tissue in different developmental stages to the 5’-flanki......
Background The relationship between signal transduction and tumors has become one of the foci in cancer research. Signal......
miR-148b-3p promotes migration of Schwann cells by targeting cullin-associated and neddylationdissoc
MicroRNAs(miRNAs) are small,non-coding RNAs that negatively adjust gene expression in multifarious biological processes.......
RNA interference (RNAi) induces gene silencing at a level of posttranscription mediated by double stranded RNA. There ar......
Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C withou
The current standard interferon-alpha(IFN-α)-based therapy for chronic hepatitis C virus(HCV) infection is only effecti......
The human ε-globin gene is expressed in a tissue-specific and developmental stage-specific manner. During the earliest......
Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C withou
The current standard interferon-alpha(IFN-α)-based therapy for chronic hepatitis C virus(HCV) infection is only effecti......
Protein inhibitor of activated STAT 4(PIAS4) regulates liver fibrosis through modulating SMAD3 activ
Excessive fibrogenesis disrupts normal liver structure,impairs liver function,and precipitates the development of cirrho......
RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells
AIM:To inhibit the expression of vascular endothelial growth factor(VEGF)in colon cancer cell line by RNA interference(R......
Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of
AIM:To identify the relationship between DNA hyper- methylation and histone modification at a hyperme- thylated,silenced......
AIM: To observe the gene silencing mediated by the specific shRNA targeted against β-catenin and its effect on cell pro......
Growth inhibition induced by short hairpin RNA to silence survivin gene in human pancreatic cancer c
BACKGROUND:Survivin is known to be overexpressed in various human malignancies,including pancreatic cancer,and mediates ......
HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemo
AIM: To investigate the expression of Hu R in pancreatic ductal adenocarcinoma(PDA) and to assess the effects of Hu R si......
Virtual design and performance prediction of a silencing air cleaner used in an I.C.engine intake sy
This paper reports results of the authors’ studies on the virtual design method used in the development of low noise in......
Eggplant(Solanum melongena)is an economically important vegetable requiring investigation into its various genomic funct......
RNA interference (RNAi) is a remarkable type of generegulation based on sequence-specific targeting anddegradation of R......
RNA interference (RNAi) is triggered by the presence of a double-stranded RNA (dsRNA), and results in the silencing of h......
In eukaryotic organisms cellular fate and tissue specific gene expression are regulated by the activity of proteins know......
Specific anti-viral effects of RNA interference on replication and expression of hepatitis B virus i
Background RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Our previous st......
Fragile X syndrome(Fra X), the most common form of inherited mental retardation, is caused by the absence of the evoluti......
Reversal of the phenotype by K-ras~(val12) silencing mediated by adenovirus-delivered siRNA in human
AIM: To investigate the in vitro antitumor effect of adenovirus-mediated small interfering RNAs (siRNAs) on pancreatic c......
Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play importan......
AC2 and AC4 proteins of Tomato yellow leaf curl China virus and Tobacco curly shoot virus mediate su
Tomato yellow leaf curl China virus Y10 isolate (TYLCCNV-Y10) alone could systemically infect host plants such as Nicoti......
siRNA-mediated silencing of Cockayne Cyndrome group B gene potentiates radiation-induced apoptosis a
Background Cockayne syndrome (CS) is a rare human genetic disorder characterized by increased UV sensitivity, developmen......
Background RNA interference using short hairpin RNA (shRNA) can mediate sequence-specific inhibition of gene expression ......
Two virus-encoded RNA silencing suppressors,P14 of Beet necrotic yellow vein virus and S6 of Rice bl
Functional analysis for gene silencing suppres- sor of P14 gene of Beet necrotic yellow vein virus and S6 gene of Rice b......
The molecular mechanisms mediating herpes simplex virus type 1 (HSV-1) gene silencing during latent infection arenot cl......
Epigenetics of human cancer becomes an area of emerging research direction due to a growing understanding ofspecific epi......
Rice gall dwarf virus(RGDV)is an important rice pathogen in China and Southeast Asia.However,little is known about the m......
AIM:To construct the CABYR RNAi plasmid and study its relation with the nuclear factor(NF)-κB signal transduction pathw......
Objective: The aim of this study was to explore the effects on malignant proliferation of A549 cell by silencing cy-cloo......
