BACKGROUND Merkel cell carcinoma(MCC)is a rare and aggressive cutaneous neuroendocrine neoplasia,with high risk of recur......

Metastatic urothelial carcinoma(mUC)is an incurable and aggressive disease.In the past decades there have been few effec......

目的:观察连续给予供试品后由于积蓄而对机体产生的毒性反应及其严重程度,提供毒性反应的器官及其损害的可逆性,确定无毒反应剂量,......

2017年,美国食品药品监督管理局(FDA)加速批准了新药Bavencio,主要成分Avelumab。该药对转移性默克尔细胞癌(mMCC)具有持续缓解作......

程序性死亡受体1/配体1(PD-1/PD-L1)作为B7/CD-28协同分子超家族的重要成员,通过抑制T细胞的活性和增殖来调控免疫应答,参与肿瘤的......

美国FDA于2017年3月23日批准Bavencio（avelumab）用于治疗转移性Merkel细胞癌（Merkel cell carcinoma,MCC）,适用于12岁及以上儿童和成人......

BACKGROUND Programmed cell death-1(PD-1)inhibitor has been indicated for many types of malignancies.However,these inhibi......