typeⅠinterferon相关论文
Oncolytic Activity of Wild-type Newcastle Disease Virus HK84 Against Hepatocellular Carcinoma Associ
Background and Aims: Hepatocellular carcinoma (HCC) is listed as one of the most common causes of cancer-related death. ......
系统性红斑狼疮是一种临床表现多样的自身免疫性疾病，其免疫紊乱机制尚未完全阐明。既往研究已经表明I型干扰素与系统性红斑狼疮密......
Raf kinase inhibitor protein and TANK-binding kinase 1 form a positive feedback loop to promote type
TANK-binding kinase 1 (TBK1) activation is a central event in type I interferon production in anti-virus innate immunity......
Interferon-inducible downregulation of microRNA-27a feedback inhibits antiviral type Ⅰ interferon pr
Type Ⅰ interferon (IFN) production plays key roles in host antiviral innate immune response, but the mechanisms for reg......
Protein phosphatase PP1 negatively regulates the Toll-like receptor-and RIG-Ⅰ-like receptor-triggere
The production of type Ⅰ interferon must be tightly regulated, and the aberrant production of this protein is harmful o......
Autotaxin is induced in response to TLR activation through Type Ⅰ interferon autocrine/paracrine loo
Lysophosphatidic acid (LPA) is an important phospholipid mediator in inflammation and immunity.However, the mechanism of......
Methyltransferase Dnmt3a Upregulates HDAC9 to Deacetylate TBK1 for Activation of Antiviral Innate Im
Epigenetic regulation of innate immunity needs further identification.Dnmt3a,a de novo DNA methyltransferase,is highly e......
Unanchored ubiquitin chain sustains RIG-Ⅰ-induced interferon-Ⅰ activation and controls selective gen
Ubiquitination plays a crucial role in retinoic acid-inducible gene Ⅰ (RIG-Ⅰ)-induced antiviral responses.However,the ......
目的利用生物信息学的分析方法研究皮肌炎(DM)基因表达谱的改变,探索DM潜在的发病机制。方法GEO数据库下载DM患者肌肉组织基因表达......
为建立一种更简便、安全、有效的检测I型干扰素（IFN）的方法，将可被I型IFN诱导的人6－16基因启动子与表达产物容易被检测的β－半乳糖苷酶......
三结构域蛋白21(TRIM21)是TRIM家族中的一员,其作为E3泛素连接酶在抗病毒天然免疫中发挥了重要作用。当病毒入侵时,TRIM21与病毒核......
为了探讨脑心肌炎病毒（EMCV）非结构蛋白3C对IFN-β信号通路的影响,采用RT-PCR方法构建EMCV 3C蛋白的重组真核表达质粒pVAX1-3C,将其......
核呼吸因子NRF1是调控细胞生长、代谢能量产生、线粒体氧化呼吸链重要基因表达的转录因子,但是在免疫中的作用尚未被报道.本研究发......
