α-SYNUCLEIN相关论文
目的:探讨胶质纤维酸性蛋白（glial fibrillary acidic protein,GFAP）与神经元α-突触核蛋白（α-synuclein）在实验性慢性氟中毒大鼠脑损......
研究背景帕金森病（PD）是一种长期的中枢神经系统退行性疾病,主要影响运动系统。衰老是帕金森疾病最重要的危险因素,全球65岁以上的人......
帕金森病(PD)是一种隐匿性和进行性发展的神经退行性疾病,在65岁以上人口中约占2％～3％,是第二大常见的神经退行性疾病.PD的致病因素尚......
目的:分析血清α-突触核蛋白(α-syn)、微小核糖核酸-214(miR-214)联合检测在帕金森病(PD)患者认知功能障碍评估中的应用价值。方......
目的:选择中脑腹侧被盖区（VTA）为目标核团,观察VTA区多巴胺转运蛋白是否参与老龄大鼠术后认知功能障碍,通过调节VTA区多巴胺转运蛋白......
目的 探究镇肝熄风汤抗1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-甲基-4-苯基-1,2,3,6-四氢吡啶,MPTP)诱导的帕金森病(PD)模型小鼠的作用......
期刊
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in
We have previously shown that roflupram (ROF) protects against MPP+-induced neuronal damage in models of Parkinson\'s ......
Abnormal accumulation of α-synuclein contributes to the formation of Lewy bodies in the substantia nigra, which is cons......
The neurotrophic signaling of glial cell line-derived neurotrophic factor (GDNF) with its canonical receptor, the recept......
热休克蛋白Hsp70 (heat shock protein 70,Hsp70)是一类广泛存在的分子伴侣.阿尔茨海默病(Alzheimer\'s disease)、帕金森病(Par......
...
α-Synuclein is a soluble monomer abundant in the central nervous system.Aggregates of α-synuclein,consisting of higher......
EFFECTS OF DOPAMINE SYNAPTIC DYSFUNCTION IN THE STRIATUM OF THE MICE OVEREXPRESSING HUMAN A-SYNUCLEI
Parkinsons disease(PD)has been viewed as a disease characterized by loss of the nigrostriatal dopaminergic projection an......
利用原子力显微镜对与帕金森相关的蛋白质α-synuclein的积聚过程进行了研究.结果表明:α-synuclein在积聚的早期阶段是以寡聚体的......
Acrylamide can form in foods during cooking process and cause multiple adverse effects.However,the neurotoxicity and mec......
Objective.The enteric nervous system(ENS)control the function of gastrointestinal tract,such as gastrointestinal motilit......
Objective:Accumulating evidence shows that α-synuclein (α-Syn) plays a key rolein the pathogenesis of Parkinsons disea......
Parkinsons disease(PD)is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the sub......
TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopamine
...
Rosmarinic acid(RA)is a naturally occurring polyphenolic compound,and is composed of caffeic acid and danshensu....
Mice expressing the A53T mutant form of human alpha-synuclein exhibit unexpected Improvements of spa
Parkinsons disease(PD)pathology is characterized by the formation of intra-neuronal inclusions called Lewy bodies,which ......
Converging lines of evidence demonstrate that intracellular accumulation of α-synuclein(α-Syn)as filamentous aggregate......
Parkinsons disease(PD)has become a social problem in China,seriously affecting population health and life quality and in......
Aging is associated with an increased risk for Parkinsons disease(PD)and dementia with Lewy bodies(DLB),in which alpha-s......
ɑ-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with redu
Abnormal α-synuclein(α-syn)expression and aggregation have been implicated in the pathogenesis of Parkinsons disease(P......
Overexpression of α-synuclein caused mitochondria vacuolization and mitochondrial membrene potential
We previously found that alpha-Synuclein (Syn) localized not only in neuclei but also in axons and cytoplasm, especially......
α-Synuclein(α-Syn)is the most abundant protein found in Lewy bodies,a hallmark of Parkinsons disease(PD).Pathological ......
Aim: Alzheimers disease (AD) and other neurodegenerative dementia belong to a family of protein mis-folding diseases.The......
Parkin ameliorates dopaminergic neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr
Mutations in the parkin gene are currently thought to be the most common cause of familial Parkinsonism.Overexpression o......
CpG methylation of alpha-Synuclein is regulated by 1-methyl-4-phenylpyridinium (MPP+) in dopaminergi
Parkinsons disease (PD) is a progressive neurodegenerative disease related to age, caused by degeneration of dopaminergi......
Parkinsons disease(PD)is a common neurodegenerative movement disorder affecting an increasing number of elderly.Various ......
TRPC3 participates in α-synuclein-induced alterations in apoptotic activity and cell stage marker ge
Olfactory impairment is one of the earliest non-motor manifestations of Parkinsons disease,which is accompanied by abnor......
The pathological α-synuclein transmission in brain of a transgenic mouse model of Alzheimer‘s diseas
Alzheimers disease(AD)and Parkinsons disease(PD)are common neurodegenerative diseases.There is comorbidity of AD and PD ......
Parkinsons disease (PD) is a chronic progressive neurodegenerative disease which was first described in 1817, affecting ......
帕金森疾病(Parkinsons disease)是全球第二高发病率的神经退行性疾病。现今研究表明,α-synuclein是帕金森疾病标志之一路易小体(......
HDAC6 regulates aggresome-autophagy degradation pathway of α-synuclein in response to MPP+-induced s
Increasing evidence suggests that the ubiquitin-binding histone deacetylase-6 (HDAC6) plays an important role in the cle......
Subcutaneous administration of rotenone has recently attracted attention because of its convenience,simplicity and effic......
α-Synuclein immunoreactivity and ultrastructural study of glial cytoplasmic inclusions in multiple s
...
目的 探讨臭氧所致的雄性小鼠神经退行性样改变及潜在机制.方法 23只C57BL/6N 7～8月龄雄性小鼠分为对照组(空气组,11只)和臭氧组(1 ......
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Misfolded α-synuclein is a major component of Lewy bodies,which are a hallmark of Parkinson\'s disease (PD).A large b......
Observation of an a-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Misfoldedα-synudein is a major component of Lewy bodies,which are a hallmark of Parkinson\s disease(PD).A large body o......
Many neurodegenerative diseases are characterized by abnormal accumulations of insoluble protein aggregates, such as......
Melatonin attenuates MPTP-induced neurotoxicity via preventing Cdk5-mediated autophagy and α-synucle
Autophagy is involved in the pathogenesis of neurodegenerative diseases including Parkinsons disease(PD).However,lit......
帕金森氏病(Parkinsons Disease, PD)是发病率位居第二的神经退行性疾病,它的主要病理特征为中脑黑质区多巴胺能神经元的进行......
Triphenyltin (TPT ) 广泛地向神经房间和相关机制遗体作为环境污染物质，而是它的毒性存在不清楚。在这研究， SHSY-5Y 房间暴露于 TP......
在帕金森病中,alpha-突触核蛋白(α-synuclein)累积与聚集所产生的细胞毒性是发病的重要原因。本文目的是探求不同亚细胞定位的α-......
目的 分析中国人群α-突触蛋白A53T基因多态性与帕金森病(Parkinson’s disease,PD)的相关性.方法 采用常规聚合酶链式反应测定224......
...
