Oral route is generally regarded as the most convenient and comfortable way of administering drugs.However, it is difficult to devour big size solid medicine (such as tablets and capsules) for sick animal, infants, children, and the elderly.Therefore, some disagreeable qualities of drug (bitterness, saltiness, sourness and so on) severely limit its application in oral administration.With this in mind, we developed a simple and efficient method to fabricate taste-masked oral drug delivery system (DDS), which regulate release of unpleasant taste drug upon the stimulation of physiological environment with changing of pH values in alimentary canal.