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5. Comparative proteomic analysis of cisplatin-and oxaliplatininduced phosphorylation in proteins bound

Comparative proteomic analysis of cisplatin-and oxaliplatininduced phosphorylation in proteins bound

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：liyanhao1986

【摘 要】

：

Cisplatin and oxaliplatin are widely used chemotherapeutic agents with different anti-tumor spectra.[1] Cisplatin is believed to covalently bind DNA nucleobases,and such Pt-DNA adducts cause replicati

【作 者】

：

Xin Yuan Wanjun Zhang Yafeng He Jian Yuan Dongfan Song Weijie Qin Hanyang Yu Zijian Guo 

【机 构】

：

State Key Laboratory of Coordination Chemistry,Coordination Chemistry Institute,School of Chemistry

【出 处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

cisplatin oxaliplatin Pt-DNA probe phosphoproteome DNA damage response 

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　　Cisplatin and oxaliplatin are widely used chemotherapeutic agents with different anti-tumor spectra.[1] Cisplatin is believed to covalently bind DNA nucleobases,and such Pt-DNA adducts cause replication and transcription blockage and ultimately leads to apoptosis.

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