Design,synthesis and preliminary anti-fibrotic activity study of 1,6-disubstituted-2(1H)-pyridone co

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  Idiopathic pulmonary fibrosis(IPF)is commonly considered the result of a recurrent injury to the alveolar epithelium followed by an uncontrolled proliferation of fibroblasts.Currently,there is no efficient therapy strategy and most patients are treated with glucocorticoids or immunosuppressants,which have various toxic effects with poor efficiency[1].Therefore,novel treatments are urgently required.
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