Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced u

来源 :2015广东省药师周大会 | 被引量 : 0次 | 上传用户：nihaochaochao

【摘要】

：

【作者】

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Kaipeng Huang Cheng Chen Jie Hao Junying Huang Shaogui Wang Peiqing Liu Heqing Huang

【出处】

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2015广东省药师周大会

【发表日期】

：

2014年6期

【关键词】

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diabetic nephropathy advanced glycation-end products oxidative stress Sirt1 poly

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　　Sirt1 and nuclear factor-E2 related factor 2 (Nrf2)-anti-oxidant response element (ARE) anti-oxidative pathway play important regulatory roles in the pathological progression of diabetic nephropathy (DN) induced by advanced glycation-end products (AGEs).Polydatin (PD),a glucoside of resveratrol,has been shown to possess strong anti-oxidative bioactivity.

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Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced u

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