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Naturally occurring hypocrellins, including hypocrellin A (HA) and hypocrellin B (HB),are well known photodynamic sensitizers and their anticancer and antiviral activities have been scrutinized against a large variety of tumor cell lines and viruses.To promote photodynamic properties, a variety of derivatives of HA and HB were synthesized with improved water solubility and/or extended absorption spectra into the phototherapeutic window of 600-900 nm.