Background The absence of blood flow or decreased blood flow in a coronary artery following pereutaneous transluminal coronary rotational atherectomy (PTCRA) despite the presence of a patent epicardial vessel is designated"no-reflow" or "impaired flow".This alteration in blood flow is a serious complication of percutaneous revascularization strategies that results in an increased incidence of morbidity, myocardial infarction and mortality.Methods Sixteen consecutive patients undergoing standard percutaneous revascularization procedures complicated by either no-reflow or impaired flow that received intracoronary nitroglycerin treatment were studied.Interventions were performed on native vessels after rotational atherectomy strategies.Following interventions that were associated with impaired flow, varying total doses (of nitroglycerin 100-400 μg) were administered into the coronary artery.The angiographic archives before and after intracoronary administration of nitroglycerin were analyzed for TIMI grade flow and a frame count method was used to quantitate blood flow velocity.The corrected TIMI frame count (cTFC), TIMI myocardial perfusion grade (TMPG) and the diameter of IRA were calculated and analyzed by Gibsons TIMI frame count method using quantitative computer angiography (QCA) system to evaluate the influence of anisodamine oncoronary flow and vessel lumen.In the meantime the invasivehemodynamic parameters of intracoronary and systemic artery (systolic, diastolic and mean pressure) and electrocardiogram (ECG) were measured and monitored.