Objective: To compare the efficacy of biodegradable versus titanium fixation systems in maxillofacial surgery, a metaanalysis was performed.Methods: MEDLINE, Cochrane Controlled trials Register, EMBASE electronic databases were searched until 31 December 2013.English studied were restricted in randomized controlled trials (RCT).Study identification, inclusion and exclusion Results: Four RCT11-4 with 334 patients were included.No significant statistically difference was found between the two groups in the mean loading force (P =.35) and good mandibular function (P =.30).However, the benefits of using biodegradable systems (fewer plate removal operations) should be confirmed during a follow-up of minimally 5 years (P ＜.05)Conclusion: This meta-analysis confirms that both biodegradable and titanium fixation systems in maxillofacial surgery yielded acceptable results.However, biodegradable system was superior in fewer plate removal operations.