The Persistence of Glutamic Acid Decarboxylase Antibody is Correlated with Clinical Characteristics

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Objective: This study aimed to investigate the persistent state of glutamic acid decarboxylase antibody (GADA)in patients with latent autoimmune diabetes in adults (LADA) and its association with clinical characteristics.Subjects and Methods:This 3-year follow-up study enrolled 107 LADA and 40 type 2 diabetic (T2D) patients from the Department of Endocrinology and Metabolism in the Second Xiangya Hospital of Central South University from 2005 to 2013.GADA titer, epitopes, and clinical characteristics (including fasting C-peptide and glycosylated hemoglobin) in LADA patients were measured annually.The relationship between the persistent state of GADA and clinical characteristics in LADA patients were investigated.
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