Lapatinib antagonizes multidrug resistance-associated protein 1 mediated multidrug resistance by inh

来源 :2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 | 被引量 : 0次 | 上传用户:haorui524
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  Lapatinib, a tyrosine kinase inhibitor (TKI), is used in the treatment of advanced or metastatic breast cancer overexpressing human epidermal receptor 2 (HER2).Lapatinib can modulate the function of ATP-binding cassette (ABC) transporters (ABCB1 and ABCG2) which are the major mechanism responsible for multidrug resistance (MDR) in cancer.In this study, we investigated the effect of lapatinib on multidrug resistance-associated protein 1(MRP1/ABCC1), MRP2 (ABCC2), MRP4 (ABCC4) and lung relative resistance protein (LRP) drug efflux pump.
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