Conditional knock-down of Dnmts in hippocampus causes memory deficits in mice

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：hnxblj

【摘要】

：

　　DNA methylation catalyzed by DNA methyltransferases (dnmt1,dnmt3a and dnmt3b) is considered to play vital roles in learning and memory.Our previous studies

【作者】

：

周宇;孔庆暖;于明;王耀慧;刘其;马泽刚;

【机构】

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青岛大学医学院生理系行为学实验室,青岛,266071

【出处】

：

中国生理学会第24届全国会员代表大会暨生理学学术大会

【发表日期】

：

2014年期

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　　DNA methylation catalyzed by DNA methyltransferases (dnmt1,dnmt3a and dnmt3b) is considered to play vital roles in learning and memory.Our previous studies revealed that conditional deletion of Dnmt1 and Dnmt3a in CaMKⅡ-expression neurons impairs hippocampus-dependent memory formation in doubleknock-out mice.

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Conditional knock-down of Dnmts in hippocampus causes memory deficits in mice

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