For patients undergoing liver resection, minimising blood loss (and hence blood transfusion) and postoperative dysfunction in the liver remnant are important endpoints.Blood loss and concomitant blood transfusion are associated with higher perioperative morbidity and mortality.Blood transfusion itselfmay result in immune modulation and lead to a detrimental effect on long term survival in cancer patients.In addition, measures to reduce the incidence and magnitude of postoperative hepatic insufficiency will also improve patient outcome.Traditional anaesthesia for patients undergoing major surgical resections for cancer would include intravenous fluid therapy aimed at optimising cardiac output and minimising metabolic disturbances such as acid-base abnormalities.