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To investigate the underlying mechanism of the protection on cerebral ischemia of ct 2-adrenergic agonist clonidine.The cerebral ischemia rat model was made by right middle cerebral artery occlusion for 2 h and reperfusion for 4 h.The Sprague Dawley rats were randomly divided into the sham-operative group, the cerebral ischemia model group, the clonidine group, the yohimbine+clonidine group and the yohimbine group.