【摘 要】
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Anticancer lytic peptides(ACLPs)are a kind of bioactive peptides derived from antimicrobial lytic peptides(AMLPs),which are part of the innate immune system
【机 构】
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BeijingKeyLaboratoryofBioprocess,CollegeofLifeScienceandTechnology,BeijingUniversityofChemicalTechno
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Anticancer lytic peptides(ACLPs)are a kind of bioactive peptides derived from antimicrobial lytic peptides(AMLPs),which are part of the innate immune system and distribute in almost all species.These lytic peptides target on the cell membranes so that they could overcome multidrug resistance.However,their application was limited by the low selectivity.In this study,a pH-sensitive ACLP,JFL10(PAWHHAFHWAWHMLHHAA),was designed using JFL0(PAWRKAFRWAWRMLKKAA)as a template,which is derived from lactoferrin,by replacing all the positively charged amino acids with histidines.
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