Protective effect of Shuangshenningxin preconditioning on mitochondrial function against ischemia/re

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：chaizw

【摘要】

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【作者】

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Xue-Ii LI Jian-xun LIU

【机构】

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Experimental Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 10

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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Shuangshenningxin ischemia/reperfusion injury mitochondria energy metabolism

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Aim: To investigate the effect of Shuangshenningxin (SSNX) on mitochondrial functional defects and metabolic derangement in myocardial ischemia/reperfusion (MI/R) injury.Methods: Rats were treated with trimetazidine (10 mg·kg-Ld-1, ig), SSNX (22.5, 45, and 90 mg·kg-1·d-1, ig) or saline for 5 d.MI/R was induced by ligation of the left anterior descending coronary artery for 40 min and releasing to promote reperfusion for 120 min on the last day of administration.Then, the activities of serum LDH and CK-MB were measured.

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Protective effect of Shuangshenningxin preconditioning on mitochondrial function against ischemia/re

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