Pharmaceutical Proteomic Analysis of OS-RC-2 Cells treated with Sorafenib

来源 :第八届中国蛋白质组学大会 | 被引量 : 0次 | 上传用户：single654321

【摘要】

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【作者】

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Bing Chen Zhizhong Xu Xuewen Jin Yuling Liu Shufang Liang

【机构】

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State Key Laboratory of Biotherapy,Sichuan University,Chengdu,610041,P.R.China

【出处】

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第八届中国蛋白质组学大会

【发表日期】

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2013年11期

【关键词】

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Pharmaceutical proteomic sorafenib SILAC annexin A6

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Sorafenib,a small-molecule drug for renal cell carcinoma (RCC),targets multiple kinases including inhibiting the serine-threoninekinases Raf-1,B-Raf and the receptor tyrosine kinase activity.The off-target of multiple target drugs may increase the therapeuticpotential of a drug,but they may also cause toxic side-effects.In order to globally elucidate drug mechanism of sorafenib,apharmaceutical proteomic analysis of OS-RC-2 cells under sorafenib treatment was investigated by a SILAC quantitative proteomicmethod.

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Pharmaceutical Proteomic Analysis of OS-RC-2 Cells treated with Sorafenib

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