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Theory of carduonephric cisharmony is of long standing,and it is extensive applied in Clinical Medicine,such as insomnia,climacteric syndrome,emission,vascular dementia,irritable bowel syndrome(IBS),and so on.Chen Shi-duo from qing dynasty pointed out that if the function between heart and kidney is balanced,then five viscera can work well.However,liver plays an important role in heart and kidney coordination,it promote the connection between heart and kidney.That saying provide a reference for later ages.Professor Wang De-ming,one of the national famous veteran doctor of TCM,holds that liver-stagnation and spleen-deficiency is only the external manifestation of IBS.In fact,its inherent essence is carduonephric cisharmony.By using the theory of carduonephric cisharmony to treat IBS enrich the methods of clinical treatment.