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Melamine (1,3,5-triazine-2,4,6-triamine) is a nitrogen-based industrial chemical, which is a toxic compound to both animals and human beings especially for infants, because it is directly connected to various diseases such as kidney stones and bladder cancer.Common methodologies used for melamine detection are mainly based on HPLC and chromatography-MS/MS, and suffer from high cost and low sensitivity problems.