Background:To discuss the dynamic changes of serum hepatitis B surface antigen(HBsAg) levels,and the serum HBsAg levels apportioned by the same hepatic parenchyma cell volume(HPCV),namely hepatic cell quantities,at different liver inflammation grades and hepatic fibrosis stages in HBeAg-positive chronic hepatitis B(CHB).Methods:152 HBeAg-positive CHB patients were recruited.The serum HBsAg levels were detected by electrochemiluminescence and the serum HBsAg apportioned by the same HPCV were figured out according to the theory of sphere geometry.The HBsAg levels were compared among different liver inflammation grades,as well as hepatic fibrosis stages,respectively.