2. 您的位置
3. 首页
4. 会议论文
5. Astrocyte-derived CXCL12 Promotes Pain Hypersensitivity through CXCR4-mediated Neuroinflammation in

Astrocyte-derived CXCL12 Promotes Pain Hypersensitivity through CXCR4-mediated Neuroinflammation in

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：yaotoumiao

【摘 要】

：

Mitogen-activated protein kinases (MAPK)-mediated chemokine-cytokine networks in glial cells are likely involved in the pathological process of spinal central sensitization, the basic mechanism underl

【作 者】

：

Xue-Ming Hu Jun-Li Cao Wen Shen 

【机 构】

：

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College Jiangsu Province Key Labor

【出 处】

：

The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年9期

【关键词】

：

Chemokine Astrocytes Microglia Mitogen-activated Protein Kinases Neuroinflammati 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Mitogen-activated protein kinases (MAPK)-mediated chemokine-cytokine networks in glial cells are likely involved in the pathological process of spinal central sensitization, the basic mechanism underlying bone cancer pain.

其他文献

Presynaptic cyclic GMP-dependent protein kinase I in nociceptors is a key determinant of spinal syna

Chronic pain represents a major challenge to clinical practice and basic science.Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery

会议

Presynaptic PKG-Ispinal LTPpain hypersensitivity

Peripheral pain is enhanced by insulin-like growth factor 1 through a G rotein-mediated stimulation

Insulin-like growth factor 1 (IGF-1) is implicated in the nociceptive (pain)sensitivity of primary afferent neurons.We found that the IGF-1 receptor (IGF-1R)functionally stimulated voltage-gated T-typ

会议

New mechanisms of metastatic bone cancer pain: cancer tissue-derived ENDOGENOUS formaldehyde activat

In recent years, our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone cancer pain.We found that cancer cells produced formaldehyde through demethylatio

会议

Bone cancer painFormaldehydeTransient receptor potential vanilloid subfamily m

Ozone interventional composite therapy for intractable PHN of irritable nociceptor type, the result

Objective Neuropathic pain (NP) is a complex, chronic painful disease and most of them are still an intractable painful disease of worldwide even at present.Post-herpetic neuralgia (PHN) is one of typ

会议

Toll-Like Receptor-4/p38 Mitogen-Activated Protein Kinase (MAPK) Signaling in the Dorsal Horn Partia

Background: Our previous research suggested that the microglial P2X4 purinoceptor (P2X4R) is involved in the activation of toll-like receptor-4 (TLR4) and the release of brain-derived neurotrophic fac

会议

cancer induced bone paintoll-like receptor-4P2X4 purinoceptorphosphorylated-p

REDOX AND ZINC-DEPENDENT MODULATION OF T-TYPE CA2+ CHANNELS IN SENSORY NEURONS CONTRIBUTES TO PERIPH

Neuropeptide substance P (SP) is both produced and released by a subset of peripheral sensory neurons that respond to tissue damage (nociceptors);these neurons also express SP receptors (NK1-3).SP exe

会议

Mechanisms underlying the peripheral sensitization of bone cancer pain

Bone cancer pain resulting from primary tumors or tumors that metastasize to bone is one of the most severe and intractable types of cancer pain, which reduces the quality of the cancer patients life.

会议

Bone cancer painPeripheral sensitizationKCNQ/M (Kv7)potassium channelP2X3 rec

Up-regulation of belta4 subunit of large-conductance Ca2+-activated potassium channels in the anteri

The large-conductance Ca2+-and voltage-gated K+ channels or BK channels are ubiquitously expressed throughout the central nervous system including the cingulate cortex and contribute to action potenti

会议

FXYD2, a γ subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammati

Objective Na+,K+-ATPase (NKA) is required to generate the resting membrane potential in neurons.Our previous study showed that activation of NKA in dorsal root ganglin (DRG) neurons by follistatin-lik

会议

FXYD2Na+K+-ATPaseinflammatory paindorsal root ganglion

Involvement of Mitochondrial Uncoupling Protein 4 in Chronic Pain via Alleviating Mitochondrial Dysf

Mitochondria are the most important organelles in neurons with essential functions, yet very little research has addressed on its potential role in pain.

会议

UCP4mitochondrial dysfunctionchronic pain