Repair of spinal cord injury (SCI) is a challenging clinical puzzle because of multiple pathological factors,including im-proper microenvironment of spinal cord,unordered growth of lesion axons,glial scar formation,and weak regeneration of mature endogenous neurons.Tissue engineering in neuroscience field can replace the anatomical structure of lesion tissue and inhibit formation of glial scars.Electrical stimulation has the ability to promote axon regeneration by adjusting the action of neural-related cells,which make it a promising approach to apply electroactive polymers as the scaffolds to offer the synergistic treatment for SCI repair (Figure 1).In this study,an injectable electroactive scaffold based on tetraaniline-mod-ified poly(ethylene glycol)-poly(lactide-coglycolide) copolymer was designed and fabricated.The composites showed favorable electroactivity and thermo-sensitive gelatinization in body temperature.In vitro,neural stem cells (NSCs) cultured on this scaffold showed non-toxic performance,increased neurite length,and enhanced neuronal differentiation after electri-cal stimulation.Subsequently,the scaffold was injected into the lesion site of the spinal cord in a rat SCI model,and electrical stimulation was then applied by embedded electrodes.A 12 week synergistic treatment of electroactive scaffold application and electrical stimulation achieved better outcomes in electrophysiology,functional recovery assessment,and relative pathol-ogy than monotherapy and control.This result confirms the validity of the synergistic treatment of electroactive scaffold and electrical stimulation.In future studies,we plan to mix NSCs and biological active molecules,such as neurotrophic factors and inhibitors into the electroactive scaffold,and hope the optimal multi-disciplinary therapy of combining tissue engineer-ing,electrical stimulation,NSCs and biological active molecules will bring an extensive prospect for SCI treatment.