【摘 要】
：
The cytochrome P450 enzymes play a critical role in the metabolism of many commonly prescribed drugs.Among them,the most important enzymes are highly polymo
【机 构】
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NationalEngineeringCenterforBiochipatShanghai,Shanghai201203,China
【出 处】
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2007年生物芯片与疾病分子分型国际研讨会(International Symposium on Biochip Tec
论文部分内容阅读
The cytochrome P450 enzymes play a critical role in the metabolism of many commonly prescribed drugs.Among them,the most important enzymes are highly polymorphic CYP2C9,CYP2C19,CYP2D6 and CYP3A5,which are responsible for about 40% of the metabolism of clinical used drugs.Here we developed a novel CYP450 oligonucleotide microarray that allow for detection of 35 known variations of CYP450 genes from a single multiplex reaction,including 22 polymorphisms of CYP2D6 gene,6 polymorphisms of CYP2C9 gene,6 polymorphisms of CYP2C19 gene and 1 polymorphism of CYP3A5 gene.
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