Mutation of a GATA1 binding site in ALAS2 intron 1 arrests erythroid development in vivo

来源 :The 2nd International Symposium on Erythrocyte Biology(2016第 | 被引量 : 0次 | 上传用户：caesarsarahluckgirl

【摘要】

：

ALAS2 encodes δ-aminolevulinate synthase,which catalyzes the rate-limiting step of heme biosynthesis in erythroid cells.ALAS2 mutations are responsible for X-linked sideroblastic anemia (XLSA),which m

【作者】

：

Yingchi Zhang Jingliao Zhang Wenbin An Yang Wan Shihui Ma Jie Yin Xichuan Li Jie Gao Weiping Yuan Ye Guo James Douglas Engel Lihong Shi Tao Cheng Xiaofan Zhu

【机构】

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State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital

【出处】

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The 2nd International Symposium on Erythrocyte Biology(2016第

【发表日期】

：

2016年10期

【关键词】

：

GATA1 XLSA ALAS2 erythroid development intronic mutation

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Mutation of a GATA1 binding site in ALAS2 intron 1 arrests erythroid development in vivo

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