【摘 要】
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Growing evidence indicates that neurotrophin-3 (NT-3), interleukin-1β (IL-1β) and spinal glia are involved in neuropathic pain derived from dorsal root ganglia (DRG) to spinal cord.Electroacupuncture
【机 构】
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Department of Physical Medicine and Rehabilitation, the Second Affiliated Hospital of Wenzhou Medica
论文部分内容阅读
Growing evidence indicates that neurotrophin-3 (NT-3), interleukin-1β (IL-1β) and spinal glia are involved in neuropathic pain derived from dorsal root ganglia (DRG) to spinal cord.Electroacupuncture (EA) is widely accepted to treat chronic pain and we have reported that EA could increase pain thresholds of rats with chronic constriction injury (CCI), but the precise mechanism underlying the analgesic effect of EA has not been fully demonstrated.In this study, we used immunofluorescence and western blots methods to investigated the effect of EA on the expression of NT-3 and IL-1 β in DRG or spinal cord of rats with CCI, we also examined the expression of spinal GFAP (astrocytic marker), OX-42 (microglial marker) in spinal cord.In present study, we found that EA promote the up-regulate expression of NT-3 in DRG and spinal cord, while EA down-regulate the expression of IL-1β in spinal cord.Additionally, Immunofluorescence exhibited that CCI-induced activation of microglia and astrocytes was inhibited significantly by EA treatment.These results demonstrate that the analgesic effect of EA may be achieved by the neural protection of NT-3, anti-inflammatory of decreasing IL-1β and inhibition the activation of spinal glia.
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